Anti-Mycobacterium tuberculosis Terpenoids from Resina Commiphora

Authors :: Xinchun Chen
Bin-Yuan Hu
Jia-Wang Liu
Yi Cai
Zongde Zhang
Da-Peng Qin
Chuanzhi Zhu
Yong-Xian Cheng
Source :: Molecules, Molecules, Vol 24, Iss 8, p 1475 (2019), Volume 24, Issue 8
Publication Year :: 2019
Publisher :: MDPI, 2019.
Abstract: Four new compounds including two new sesquiterpenoid dimers, commiphoroids E (1) and F (2), a new triterpenoid (3), and a new sesquiterpenoid (4), along with three known terpenoids (5&minus<br />7) were isolated from Resina Commiphora, whose structures were identified by NMR spectra, HRESIMS, and X-ray diffraction analysis. Compounds 1 and 2 both bear an O-bridge ring and feature a plausible [4 + 2] Diels&ndash<br />Alder cycloaddition reaction. Antimycobacterial activities show that all the tested compounds (200 &mu<br />M) could inhibit the growth of both sensitive and clinically multi-drug resistant (MDR) isolated strains. In addition, cellular toxicity of the isolates against human cancer cells and THP-1 monocyte cells was examined.

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