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Influenza A(H5N1) viruses with A(H9N2) single gene (matrix or PB1) reassortment isolated from Cambodian live bird markets

Authors :
Paul F. Horwood
Andrew R. Greenhill
Aeron C. Hurt
Sokhoun Yann
San Sorn
Songha Tok
Davun Holl
Annika Suttie
Srey Viseth Horm
Yi-Mo Deng
Erik A. Karlsson
Philippe Dussart
Sothyra Tum
Ian G. Barr
Unité de Virologie / Virology Unit [Phnom Penh]
Institut Pasteur du Cambodge
Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)
Federation University [Churchill, Australia]
The Peter Doherty Institute for Infection and Immunity [Melbourne]
The Royal Melbourne Hospital-University of Melbourne
Ministry of Agriculture, Forestry and Fisheries [Cambodia]
James Cook University (JCU)
This publication is the result of work conducted under a cooperative agreement with the Office of the Assistant Secretary for Preparedness and Response in the U.S. Department of Health and Human Services (HHS), grant number IDSEP140020-01-00. Its contents and conclusions are solely the responsibility of the authors and do not represent the official views of HHS. The study was also funded, in part, by the US Agency for International Development (grant No. AID-442-G-14-00005). Annika Suttie is funded by an Australian Government Research Training Program Scholarship and a Faculty of Science and Technology Research Scholarship from Federation University. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health.
Source :
Virology, Virology, Elsevier, 2018, 523, pp.22-26. ⟨10.1016/j.virol.2018.07.028⟩
Publication Year :
2018
Publisher :
Elsevier BV, 2018.

Abstract

International audience; Live bird market surveillance for avian influenza viruses in Cambodia in 2015 has led to the detection of two 7:1 reassortant influenza A(H5N1) clade 2.3.2.1c viruses. These reassortant strains, designated A/duck/Cambodia/ Z564W35M1/2015 and A/chicken/Cambodia/Z850W49M1/2015, both contained a single gene (PB1 and matrix gene, respectively) from concurrently circulating A(H9N2) influenza viruses. All other viral genes from both isolates clustered with A(H5N1) clade 2.3.2.1 viruses. Continued and prolonged co-circulation of influenza A(H5N1) and A(H9N2) viruses in Cambodian live bird markets may present a risk for the emergence of novel influenza reassortant viruses with negative agricultural and/or public health implications.

Subjects

Subjects :
0301 basic medicine
animal diseases
viruses
Reassortment
Gene Expression
medicine.disease_cause
A(H5N1)
MESH: Ducks
Influenza A Virus, H9N2 Subtype
MESH: Animals
MESH: Phylogeny
Clade
Phylogeny
2. Zero hunger
Live bird markets
MESH: Chickens
virus diseases
3. Good health
MESH: Reassortant Viruses
Ducks
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Epidemiological Monitoring
Cambodia
Reassortant Viruses
MESH: Gene Expression
MESH: Influenza A Virus, H5N1 Subtype
Single gene
MESH: Poultry Diseases
Biology
Viral Matrix Proteins
Viral Proteins
03 medical and health sciences
MESH: Influenza in Birds
Phylogenetics
Virology
medicine
Animals
Gene
Poultry Diseases
MESH: Viral Matrix Proteins
Viral matrix protein
Influenza A Virus, H5N1 Subtype
MESH: Cambodia
MESH: Viral Proteins
Influenza
Influenza A virus subtype H5N1
MESH: Influenza A Virus, H9N2 Subtype
030104 developmental biology
Influenza in Birds
MESH: Epidemiological Monitoring
Chickens
A(H9N2)

Details

ISSN :
00426822 and 10960341
Volume :
523
Database :
OpenAIRE
Journal :
Virology
Accession number :
edsair.doi.dedup.....9458a1c49c25e92abcc61123632ca053

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