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Saralasin infusion in the recognition of renovascular hypertension
- Source :
- Annals of internal medicine. 87(1)
- Publication Year :
- 1977
-
Abstract
- Saralasin, an angiotensin II antagonist, was infused into 49 patients with renal artery stenosis, 10 patients with essential hypertension and normal renal arteriograms, and five patients with "low-renin essential hypertension." Renal venous renin and differential renal function studies were used to assess the functional significance of arterial stenoses. "Response" to saralasin, evidenced by a fall in blood pressure during infusion, occurred in no patients with "low renin" hypertension and in only 20% of patients with normal renal arteriograms. In contrast, saralasin "response" occurred in more than 80% of patients with renal artery stenosis and lateralizing functional studies and 100% of cases of "proven" renovascular hypertension (cure or improvement of hypertension after operative treatment). We suggest that saralasin infusion might be a valuable screening test for the recognition of renovascular hypertension.
- Subjects :
- medicine.medical_specialty
Hypertension, Renal
medicine.medical_treatment
Renal Artery Obstruction
Blood Pressure
urologic and male genital diseases
Essential hypertension
Renal artery stenosis
Nephrectomy
Renovascular hypertension
Diagnosis, Differential
chemistry.chemical_compound
Internal medicine
Renin
Internal Medicine
medicine
Humans
business.industry
Angiotensin II
General Medicine
medicine.disease
Blood pressure
chemistry
Hypertension
Cardiology
business
Saralasin
Subjects
Details
- ISSN :
- 00034819
- Volume :
- 87
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Annals of internal medicine
- Accession number :
- edsair.doi.dedup.....9455b50d4efb34296c672bf64fe2e954