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Height Adjustment in Assessing Dual Energy X-Ray Absorptiometry Measurements of Bone Mass and Density in Children
- Source :
- The Journal of Clinical Endocrinology & Metabolism. 95:1265-1273
- Publication Year :
- 2010
- Publisher :
- The Endocrine Society, 2010.
-
Abstract
- In children, bone mineral content (BMC) and bone mineral density (BMD) measurements by dual-energy x-ray absorptiometry (DXA) are affected by height status. No consensus exists on how to adjust BMC or BMD (BMC/BMD) measurements for short or tall stature.The aim of this study was to compare various methods to adjust BMC/BMD for height in healthy children.Data from the Bone Mineral Density in Childhood Study (BMDCS) were used to develop adjustment methods that were validated using an independent cross-sectional sample of healthy children from the Reference Data Project (RDP).We conducted the study in five clinical centers in the United States.We included 1546 BMDCS and 650 RDP participants (7 to 17 yr of age, 50% female).No interventions were used.We measured spine and whole body (WB) BMC and BMD Z-scores for age (BMC/BMD(age)), height age (BMC/BMD(height age)), height (BMC(height)), bone mineral apparent density (BMAD(age)), and height-for-age Z-score (HAZ) (BMC/BMD(haz)).Spine and WB BMC/BMD(age)Z and BMAD(age)Z were positively (P0.005; r = 0.11 to 0.64) associated with HAZ. Spine BMD(haz) and BMC(haz)Z were not associated with HAZ; WB BMC(haz)Z was modestly associated with HAZ (r = 0.14; P = 0.0003). All other adjustment methods were negatively associated with HAZ (P0.005; r = -0.20 to -0.34). The deviation between adjusted and BMC/BMD(age) Z-scores was associated with age for most measures (P0.005) except for BMC/BMD(haz).Most methods to adjust BMC/BMD Z-scores for height were biased by age and/or HAZ. Adjustments using HAZ were least biased relative to HAZ and age and can be used to evaluate the effect of short or tall stature on BMC/BMD Z-scores.
- Subjects :
- Male
musculoskeletal diseases
medicine.medical_specialty
Adolescent
Bone density
Cross-sectional study
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Context (language use)
Biochemistry
Bone and Bones
Absorptiometry, Photon
Child Development
Sex Factors
Endocrinology
Bone Density
Reference Values
Internal medicine
medicine
Humans
Child
Dual-energy X-ray absorptiometry
Orthodontics
Bone mineral
medicine.diagnostic_test
business.industry
musculoskeletal, neural, and ocular physiology
Biochemistry (medical)
Age Factors
Tall Stature
Adolescent Development
musculoskeletal system
Body Height
humanities
Surgery
Cross-Sectional Studies
Regression Analysis
Female
Original Article
Densitometry
business
human activities
Bone mass
Subjects
Details
- ISSN :
- 19457197 and 0021972X
- Volume :
- 95
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Endocrinology & Metabolism
- Accession number :
- edsair.doi.dedup.....9454724bc22ff314cb051b1c6b025d0a