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The potential nutrigeroprotective role of Mediterranean diet and its functional components on telomere length dynamics
- Source :
- Ageing research reviews. 49
- Publication Year :
- 2018
-
Abstract
- The Mediterranean diet (MD) is a gold standard for nutrition and the most evidence-based diet to delay the onset of age-associated pathologies. Telomeres are the heterochromatic repeat regions found at the ends of eukaryotic chromosomes, whose length is considered a reliable hallmark of biological ageing. Telomere shortening is, at least in part, a modifiable factor and there is evidence that adherence to the MD is associated with longer telomeres. Data from several studies indicate an association between “inflammatory/oxidative status” and telomere length (TL). The MD, as a complex exposome with thousands of nutrients and phytochemicals, may positively influence telomere attrition by reducing inflammation and oxidative stress. However, it is unclear whether the protective effects on TL provided by the MD result from its individual constituents or some combination of these. Furthermore, these properties of the MD and its components are not yet fully validated by clinical endpoints in randomized trials or observational studies. Here, we summarize the data from experimental and population-based studies on the effects of the MD on TL maintenance. We will both highlight the possible role of the MD in the prevention of age-associated diseases, and attempt to identify certain aspects of the diet that are particularly important for telomere maintenance.
- Subjects :
- 0301 basic medicine
Exposome
Aging
Mediterranean diet
Heterochromatin
Population
Phytochemicals
Nutritional Status
Phytochemical
Biology
Bioinformatics
Diet, Mediterranean
Biochemistry
03 medical and health sciences
0302 clinical medicine
Risk Factors
Ageing
Food
Telomere
Biotechnology
Molecular Biology
Neurology
Humans
education
Telomere Shortening
Inflammation
education.field_of_study
Telomere Homeostasis
Epidemiologic Studies
030104 developmental biology
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18729649
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Ageing research reviews
- Accession number :
- edsair.doi.dedup.....945068cecd9da2f6363889f9819a0391