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A Stochastic Model for Wound Healing

Authors :
Thomas Callaghan
Leonard M. Sander
Robert M. Ziff
Evgeniy Khain
Source :
Journal of Statistical Physics. 122:909-924
Publication Year :
2006
Publisher :
Springer Science and Business Media LLC, 2006.

Abstract

We present a discrete stochastic model which represents many of the salient features of the biological process of wound healing. The model describes fronts of cells invading a wound. We have numerical results in one and two dimensions. In one dimension we can give analytic results for the front speed as a power series expansion in a parameter, p, that gives the relative size of proliferation and diffusion processes for the invading cells. In two dimensions the model becomes the Eden model for p near 1. In both one and two dimensions for small p, front propagation for this model should approach that of the Fisher-Kolmogorov equation. However, as in other cases, this discrete model approaches Fisher-Kolmogorov behavior slowly.<br />16 pages, 7 figures

Details

ISSN :
15729613 and 00224715
Volume :
122
Database :
OpenAIRE
Journal :
Journal of Statistical Physics
Accession number :
edsair.doi.dedup.....9443dd046dbbdfb0c3ac572507b00020