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Prognostic Value of Baseline Radiomic Features of 18F-FDG PET in Patients with Diffuse Large B-Cell Lymphoma
- Source :
- Diagnostics, Diagnostics, Vol 11, Iss 36, p 36 (2021), Diagnostics; Volume 11; Issue 1; Pages: 36
- Publication Year :
- 2020
- Publisher :
- MDPI, 2020.
-
Abstract
- This study investigates whether baseline 18F-FDG PET radiomic features can predict survival outcomes in patients with diffuse large B-cell lymphoma (DLBCL). We retrospectively enrolled 83 patients diagnosed with DLBCL who underwent 18F-FDG PET scans before treatment. The patients were divided into the training cohort (n = 58) and the validation cohort (n = 25). Eighty radiomic features were extracted from the PET images for each patient. Least absolute shrinkage and selection operator regression were used to reduce the dimensionality within radiomic features. Cox proportional hazards model was used to determine the prognostic factors for progression-free survival (PFS) and overall survival (OS). A prognostic stratification model was built in the training cohort and validated in the validation cohort using Kaplan–Meier survival analysis. In the training cohort, run length non-uniformity (RLN), extracted from a gray level run length matrix (GLRLM), was independently associated with PFS (hazard ratio (HR) = 15.7, p = 0.007) and OS (HR = 8.64, p = 0.040). The International Prognostic Index was an independent prognostic factor for OS (HR = 2.63, p = 0.049). A prognostic stratification model was devised based on both risk factors, which allowed identification of three risk groups for PFS and OS in the training (p < 0.001 and p < 0.001) and validation (p < 0.001 and p = 0.020) cohorts. Our results indicate that the baseline 18F-FDG PET radiomic feature, RLNGLRLM, is an independent prognostic factor for survival outcomes. Furthermore, we propose a prognostic stratification model that may enable tailored therapeutic strategies for patients with DLBCL.
- Subjects :
- Oncology
18F-FDG
PET
radiomics
prognosis
diffuse large B-cell lymphoma
medicine.medical_specialty
Clinical Biochemistry
Article
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
International Prognostic Index
Internal medicine
medicine
In patient
Survival analysis
lcsh:R5-920
business.industry
Proportional hazards model
Hazard ratio
medicine.disease
Lymphoma
Gray level
030220 oncology & carcinogenesis
business
lcsh:Medicine (General)
Diffuse large B-cell lymphoma
Subjects
Details
- Language :
- English
- ISSN :
- 20754418
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Diagnostics
- Accession number :
- edsair.doi.dedup.....943fd5d7a56ccefd6166f9a2ca59bbd1