Back to Search
Start Over
Hepatoprotective action of PGE1 analogue estimated by measuring the concentrations of acetoacetate and beta-hydroxybutyrate
- Source :
- Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 55(2-3)
- Publication Year :
- 2003
-
Abstract
- The research was carried out on 56 Chinchilla rabbits. The rabbits were divided into 8 groups with one control group. By means of stomach tube the rabbits were administered respectively: carbon tetrachloride (CCl4), synthetic analogue of prostaglandin misoprostol, CCl4 with misoprostol, indomethacin, misoprostol with indomethacin and CCl4 with misoprostol and indomethacin simultaneously. In order to confirm cytoprotective activity of prostaglandin E1 synthetic analogue in experimental acute hepatocellular damage, we measured in arterial blood the concentration of acetoacetate and beta-hydroxybutyrate and calculated molar ratio of their concentrations. The molar ratio of acetoacetate to beta-hydroxybutyrate which had been calculated for individual groups, regardless of the observed changes in ketone bodies' concentrations, in the case of rabbits which were administered CCl4 with misoprostol, had values similar to the ones obtained for the control group. The smallest value of the ketone body concentration ratio was stated at rabbits which were given only CCl4. The results of the research carried out unambiguously indicate hepatoprotective action of the synthetic analogue PGE1 which was administered to the rabbits.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
biology.animal_breed
Indomethacin
Prostaglandin
Administration, Oral
Ketone Bodies
Toxicology
Liver Cirrhosis, Experimental
digestive system
Pathology and Forensic Medicine
Acetoacetates
chemistry.chemical_compound
Internal medicine
Medicine
Animals
Aspartate Aminotransferases
Prostaglandin E1
Misoprostol
Carbon Tetrachloride
biology
3-Hydroxybutyric Acid
business.industry
Alanine Transaminase
Cell Biology
General Medicine
Chinchilla rabbit
digestive system diseases
Disease Models, Animal
Endocrinology
chemistry
Acute Disease
Carbon tetrachloride
Ketone bodies
Arterial blood
Drug Therapy, Combination
Rabbits
business
Prostaglandin E
medicine.drug
Subjects
Details
- ISSN :
- 09402993
- Volume :
- 55
- Issue :
- 2-3
- Database :
- OpenAIRE
- Journal :
- Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
- Accession number :
- edsair.doi.dedup.....942952d96d625fbb04a1505704f37ed4