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LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function
- Source :
- Journal of Lipid Research, 54(2), 358-364. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Journal of Lipid Research, Vol 54, Iss 2, Pp 358-364 (2013), Journal of lipid research, 54(2), 358-364. American Society for Biochemistry and Molecular Biology Inc.
- Publication Year :
- 2013
- Publisher :
- AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2013.
-
Abstract
- containing lipoproteins can provide cholesterol for synthesis of glucocorticoids. Here we assessed adrenal glucocorticoid function in LCAT knockout (KO) mice to determine the specific contribution of HDL-cholesteryl esters to adrenal glucocorticoid output in vivo. LCAT KO mice exhibit an 8-fold higher plasma free cholesterol-to-cholesteryl ester ratio (P
- Subjects :
- medicine.medical_specialty
cholesteryl esters
lecithin:cholesterol acyltransferase
STEROIDOGENESIS
QD415-436
Adrenocorticotropic hormone
Biology
Biochemistry
Phosphatidylcholine-Sterol O-Acyltransferase
Gene Knockout Techniques
Mice
chemistry.chemical_compound
Endocrinology
Zona fasciculata
Corticosterone
Internal medicine
Adrenal Glands
medicine
Animals
Research Articles
TUMOR-NECROSIS-FACTOR
Triglyceride
glucocorticoids
APOLIPOPROTEIN-A-I
Cholesterol
LECITHIN-CHOLESTEROL ACYLTRANSFERASE
STEROID-PRODUCTION
SR-BI
Cell Biology
Up-Regulation
ADRENOCORTICAL-CELLS
medicine.anatomical_structure
chemistry
LDL receptor
HIGH-DENSITY-LIPOPROTEINS
Hepatocytes
RECEPTOR CLASS-B
SELECTIVE UPTAKE
lipids (amino acids, peptides, and proteins)
Cholesterol Esters
Lipoproteins, HDL
Glucocorticoid
medicine.drug
Lipoprotein
Subjects
Details
- Language :
- English
- ISSN :
- 00222275
- Volume :
- 54
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of Lipid Research
- Accession number :
- edsair.doi.dedup.....9426260d31bd3713aa7b30737f529ae0