Back to Search
Start Over
Effects of voluntary exercise on tumorigenesis in the C3(1)/SV40Tag transgenic mouse model of breast cancer
- Source :
- International Journal of Oncology. 42:1466-1472
- Publication Year :
- 2013
- Publisher :
- Spandidos Publications, 2013.
-
Abstract
- Epidemiologic studies suggest an association between physical activity (PA) and breast cancer risk. We examined the relationship between voluntary wheel running and breast cancer in C3(1)/SV40Tag mice. Female FVB/N and C3(1)/SV40Tag mice were assigned to either PA [C3(1)-PA] (n=12) or sedentary (Sed) [C3(1)-Sed] (n=15) treatment and were placed in a cage with access to a running wheel (PA) or without (Sed) from 4 to 24 weeks of age (sacrifice). Physical activity data were analyzed for running distance, time and speed. Body composition was examined at 12 weeks of age. Tumors were counted twice weekly and at sacrifice to assess multiplicity. Tumor volume was calculated using external calipers [0.52 x (largest diameter) x (smallest diameter)2]. Heart and body weight were also recorded at sacrifice. Results showed that voluntary wheel running reduced tumor volume per tumor [C3(1)-Sed, 422.3±89.9 mm(3); C3(1)-PA, 260.2±61.7 mm(3)] (P
- Subjects :
- Genetically modified mouse
Cancer Research
medicine.medical_specialty
Pathology
Mice, Transgenic
Tumor initiation
Motor Activity
medicine.disease_cause
Mice
Breast cancer
Internal medicine
medicine
Animals
Humans
computer.programming_language
Oncogene
sed
business.industry
Mammary Neoplasms, Experimental
Cancer
medicine.disease
Molecular medicine
Tumor Burden
Cell Transformation, Neoplastic
Endocrinology
Oncology
Female
business
Carcinogenesis
computer
Subjects
Details
- ISSN :
- 17912423 and 10196439
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- International Journal of Oncology
- Accession number :
- edsair.doi.dedup.....94207ca91317448e992b771169bddd44