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Ets-1 Maintains IL-7 Receptor Expression in Peripheral T Cells
- Source :
- The Journal of Immunology. 186:969-976
- Publication Year :
- 2011
- Publisher :
- The American Association of Immunologists, 2011.
-
Abstract
- The expression of CD127, the IL-7–binding subunit of the IL-7 R, is tightly regulated during the development and activation of T cells and is reduced during chronic viral infection. However, the molecular mechanism regulating the dynamic expression of CD127 is still poorly understood. In this study, we report that the transcription factor Ets-1 is required for maintaining the expression of CD127 in murine peripheral T cells. Ets-1 binds to and activates the CD127 promoter, and its absence leads to reduced CD127 expression, attenuated IL-7 signaling, and impaired IL-7–dependent homeostatic proliferation of T cells. The expression of CD127 and Ets-1 is strongly correlated in human T cells. Both CD127 and Ets-1 expression are decreased in CD8+ T cells during HIV infection. In addition, HIV-associated loss of CD127 is only observed in Ets-1low effector memory and central memory but not in Ets-1high naive CD8+ T cells. Taken together, our data identify Ets-1 as a critical regulator of CD127 expression in T cells.
- Subjects :
- Male
Immunology
chemical and pharmacologic phenomena
Biology
Jurkat cells
Article
Interleukin-7 Receptor alpha Subunit
Proto-Oncogene Protein c-ets-1
Mice
Interleukin 21
T-Lymphocyte Subsets
Animals
Humans
Immunology and Allergy
Cytotoxic T cell
IL-2 receptor
Promoter Regions, Genetic
Antigen-presenting cell
Cells, Cultured
Interleukin 3
Mice, Knockout
Interleukin-7
ZAP70
virus diseases
hemic and immune systems
Natural killer T cell
Molecular biology
HIV-1
Female
Protein Binding
Subjects
Details
- ISSN :
- 15506606 and 00221767
- Volume :
- 186
- Database :
- OpenAIRE
- Journal :
- The Journal of Immunology
- Accession number :
- edsair.doi.dedup.....940b2cfb49e5431594cd6f1dbbf3058b