Syntheses and Antibacterial Properties of iso-Platencin, Cl-iso-Platencin and Cl-Platencin: Identification of a New Lead Structure

Platencin is a novel antibiotic which is active against multiresistant pathogens. We describe efficient syntheses of three platencin analogues of varying activities which allow further conclusions about the pharmacophoric part of the molecule. The unnatural antibiotic iso-platencin, which is about as active as natural platencin, but much more selective, was identified as a new lead structure.