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Tunable Two-Compartment On-Demand Sustained Drug Release Based on Lipid Gels
- Source :
- Journal of Pharmaceutical Sciences. 109:1059-1067
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- The binary-lipid system of soybean phosphatidylcholine (SPC) and glycerol dioleate (GDO) can hydrate to gels on contacting with aqueous mediums, which has emerged as a versatile and promising delivery matrix for extended drug release applications. In the present work, we have characterized the gelation process of this SPC/GDO lyotropic gel (SGLG) system by rheology and evaluated the drug release profiles from the SGLG formulations with different SPC/GDO mass ratios. Our study has demonstrated that simply adjusting the SPC/GDO mass ratio can tune the lipid gelation behavior and modulate the drug release profiles. More importantly, the drug release from the SGLG formulations follows a two-compartment (fast and slow release compartments) release kinetics that has not been reported before. We posit that the fast release compartment corresponds to the passive diffusion of the drug during the early stage of the gel formation. After the boundary gel phase generation, the drug release is then dominated by the slow diffusion process from SGLG. The pharmacokinetic studies in rats match well with the in vitro studies, suggesting that the binary-lipid formulation is an excellent candidate for on-demand sustained drug delivery system.
- Subjects :
- Drug
Diffusion
media_common.quotation_subject
Kinetics
Pharmaceutical Science
02 engineering and technology
030226 pharmacology & pharmacy
03 medical and health sciences
chemistry.chemical_compound
Drug Delivery Systems
0302 clinical medicine
Pharmacokinetics
Phosphatidylcholine
Lyotropic
Animals
media_common
Aqueous solution
fungi
021001 nanoscience & nanotechnology
Lipids
Rats
Drug Liberation
chemistry
Delayed-Action Preparations
Drug delivery
Biophysics
Rheology
0210 nano-technology
Gels
Subjects
Details
- ISSN :
- 00223549
- Volume :
- 109
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmaceutical Sciences
- Accession number :
- edsair.doi.dedup.....9406c4692090e30dae12c8f520edb93a