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Life Before Seventeen
- Publication Year :
- 2011
-
Abstract
- Herpesvirus Saimiri gene 13 (HVS13) exhibits 57% identity with the predicted sequence of a T cell-derived molecule termed CTLA8. Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-kappaB activity and Interleukin-6 (IL-6) secretion in fibroblasts, and costimulate T cell proliferation. An HVS13.Fc fusion protein was used to isolate a cDNA encoding a novel receptor that also binds CTLA8. This receptor is unrelated to previously identified cytokine receptor families. A recombinant soluble receptor inhibited T cell proliferation and IL-2 production induced by PHA, concanavalin A (conA), and anti-TCR MAb. These results define CTLA8 and HVS13 as novel cytokines that bind to a novel cytokine receptor. We propose to call these molecules IL-17, vIL-17, and IL-17R, respectively.
- Subjects :
- viruses
Immunology
Molecular Sequence Data
Biology
Article
Herpesvirus 2, Saimiriine
chemistry.chemical_compound
Mice
Immune system
Il 17 receptor
Cell Line, Tumor
Immunology and Allergy
Animals
Humans
Amino Acid Sequence
Receptor
Cloning
Receptors, Interleukin-17
Base Sequence
Extramural
Interleukin-17
Pattern recognition receptor
History, 20th Century
Virology
Rats
Repressor Proteins
chemistry
Trans-Activators
Aotidae
Signal transduction
DNA
Protein Binding
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....93fb3d78acbbdac65a6fc106c656bb81