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White matter changes in patients with amnestic mild cognitive impairment detected by diffusion tensor imaging
- Source :
- PLoS ONE, Vol 8, Iss 3, p e59440 (2013), PLoS ONE
- Publication Year :
- 2013
- Publisher :
- Public Library of Science (PLoS), 2013.
-
Abstract
- Compared to normal aging adults, individuals with amnestic mild cognitive impairment (aMCI) have significantly increased risk for progressing into Alzheimer's disease (AD). Autopsy studies found that most of the brains of aMCI cases showed anatomical features associated with AD pathology. The recent development of non-invasive neuroimaging technique, such as diffusion tensor imaging (DTI), makes it possible to investigate the microstructures of the cerebral white matter in vivo. We hypothesized that disrupted white matter (WM) integrity existed in aMCI. So we used DTI technique, by measuring fractional anisotropy (FA) and mean diffusivity (MD), to test the brain structures involved in patients with aMCI. DTI scans were collected from 40 patients with aMCI, and 28 normal controls (NC). Tract-based spatial statistics (TBSS) analyses of whole-brain FA and MD images in each individual and group comparisons were carried out. Compared to NC, aMCI patients showed significant FA reduction bilaterally, in the association and projection fibers of frontal, parietal, and temporal lobes, corpus callosum, bilateral corona radiation, right posterior thalamic radiation and right sagittal stratum. aMCI patients also showed significantly increased MD widespreadly in the association and projection fibers of frontal, parietal and temporal lobes, and corpus callosum. Assessment of the WM integrity of the frontal, parietal, temporal lobes, and corpus callosum by using DTI measures may aid early diagnosis of aMCI.
- Subjects :
- Male
Cognitive Neuroscience
lcsh:Medicine
Neuroimaging
Corpus callosum
behavioral disciplines and activities
Diagnostic Radiology
Corpus Callosum
Temporal lobe
White matter
Limbic system
Diagnostic Medicine
Alzheimer Disease
Fractional anisotropy
mental disorders
Limbic System
medicine
Humans
Cognitive Dysfunction
lcsh:Science
Biology
Aged
Clinical Neurophysiology
Multidisciplinary
Cognitive Neurology
business.industry
lcsh:R
Brain
Anatomy
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Diffusion Tensor Imaging
medicine.anatomical_structure
Neurology
Case-Control Studies
Medicine
Dementia
Female
lcsh:Q
Amnesia
Nerve Net
Alzheimer's disease
Radiology
business
Research Article
Neuroscience
Diffusion MRI
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 8
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....93f86aeed98a9f871ff9053bbf82642c