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Protective effect of homovanillyl alcohol on cardiovascular disease and total mortality: virgin olive oil, wine, and catechol-methylathion
- Source :
- The American Journal of Clinical Nutrition. 105:1297-1304
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background: Hydroxytyrosol is a phenolic compound that is present in virgin olive oil (VOO) and wine. Hydroxytyrosol-related foods have been shown to protect against cardiovascular disease (CVD).Objective: We investigated the associations between hydroxytyrosol and its biological metabolite, 3-O-methyl-hydroxytyrosol, also known as homovanillyl alcohol (HVAL), with CVD and total mortality.Design: We included 1851 men and women with a mean ± SD age of 66.8 ± 6 y at high risk of CVD from prospective cohort data. The primary endpoint was a composite of myocardial infarction, stroke, and death from cardiovascular causes; the secondary endpoint was all-cause mortality. Twenty-four-hour urinary hydroxytyrosol and HVAL and catechol-O-methyltransferase (COMT) rs4680 genotypes were measured.Results: After multivariable adjustment, all biomarkers were associated, as a continuous variable, with lower CVD risk, but only HVAL showed a strong inverse association (HR: 0.44; 95% CI: 0.25, 0.80) for the comparison between quintiles. Only HVAL, as a continuous variable, was associated with total mortality (HR: 0.81; 95% CI: 0.70, 0.95). Individuals in the highest quintile of HVAL compared with the lowest had 9.2 (95% CI: 3.5, 20.8) and 6.3 (95% CI: 2.3, 12.1) additional years of life or years free of CVD, respectively, after 65 y. Individuals with the rs4680GG genotype had the highest HVAL concentrations (P = 0.05). There was no association between COMT genotypes and events or interaction between COMT genotypes and HVAL concentrations.Conclusions: We report, for the first time to our knowledge, an independent association between high urinary HVAL concentrations and a lower risk of CVD and total mortality in elderly individuals. VOO and wine consumption and a high metabolic COMT capacity for methylation are key factors for high HVAL concentrations. The association that stems from our results reinforces the benefits of 2 key components of the Mediterranean diet (wine and VOO). This trial was registered at www.predimed.es as ISRCTN35739639.
- Subjects :
- Male
medicine.medical_specialty
Genotype
Mediterranean diet
Catechols
Myocardial Infarction
Medicine (miscellaneous)
Wine
030204 cardiovascular system & hematology
Catechol O-Methyltransferase
Lower risk
Methylation
Gastroenterology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Phenols
Cause of Death
Internal medicine
Homovanillyl alcohol
medicine
Clinical endpoint
Humans
030212 general & internal medicine
Prospective cohort study
Olive Oil
Aged
Nutrition and Dietetics
Catechol-O-methyl transferase
business.industry
Homovanillic Acid
Middle Aged
Phenylethyl Alcohol
Diet
Stroke
chemistry
Cardiovascular Diseases
Hydroxytyrosol
Female
business
Biomarkers
rs4680
Subjects
Details
- ISSN :
- 00029165
- Volume :
- 105
- Database :
- OpenAIRE
- Journal :
- The American Journal of Clinical Nutrition
- Accession number :
- edsair.doi.dedup.....93f04ebfccf8bf16c0377af0a639ddf2