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Helicobacter bilis colonization of the biliary system in patients with pancreaticobiliary maljunction
- Source :
- The British journal of surgery. 97(4)
- Publication Year :
- 2010
-
Abstract
- Background Helicobacter bilis is considered to be a causative factor in the pathogenesis of biliary cancer. This study investigated the prevalence of H. bilis colonization of the biliary system of patients with pancreaticobiliary maljunction (PBM). Methods Bile juice and biliary tissue samples were collected from 17 patients with PBM and 27 controls who had benign biliary disease without PBM. DNA extracted from each biliary sample was subjected to polymerase chain reaction (PCR) analysis for H. bilis and Helicobacter pylori. Results PCR assays revealed that 12 of the 17 patients with PBM were positive for H. bilis DNA, compared with eight of 27 patients without PBM (P = 0·009). Among patients with PBM, H. bilis DNA was identified in six of eight children, including a 2-month-old infant, and in six of nine adults. The high prevalence of H. bilis DNA in the biliary system of patients with PBM was independent of age, sex, common bile duct dilatation, configuration of the pancreatic and bile ducts, and amylase activity in bile. Conclusion H. bilis colonization of the biliary system is extremely common in patients with PBM. This may point to a role in the pathogenesis of biliary cancer.
- Subjects :
- Adult
Electrophoresis
Male
medicine.medical_specialty
Helicobacter bilis
Pathology
Adolescent
Gastroenterology
Polymerase Chain Reaction
Helicobacter Infections
Biliary disease
Internal medicine
Helicobacter
medicine
Bile
Humans
Biliary Tract
Child
Aged
Biliary tract neoplasm
biology
Common bile duct
business.industry
Pancreatic Ducts
Infant
Helicobacter pylori
Middle Aged
medicine.disease
biology.organism_classification
RNA, Bacterial
medicine.anatomical_structure
Biliary Tract Neoplasms
Pancreaticobiliary maljunction
Biliary tract
Case-Control Studies
Child, Preschool
Surgery
Female
Bile Ducts
business
Subjects
Details
- ISSN :
- 13652168
- Volume :
- 97
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The British journal of surgery
- Accession number :
- edsair.doi.dedup.....93ea4c3d130029812f90e3fc8ad78d68