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Transplantation of oligodendrocyte precursor cells improves myelination and promotes functional recovery after spinal cord injury
- Source :
- Injury. 43(6)
- Publication Year :
- 2011
-
Abstract
- Loss of oligodendrocytes and demyelination further impair neural function after spinal cord injury (SCI). Replacement of lost oligodendrocytes and improvement of myelination have a therapeutic significance in treatment of SCI. Here, we transplanted oligodendrocyte precursor cells (OPCs) to improve myelination in a rat model of contusive SCI. The labelled OPCs were transplanted to injured cord 7 days after injury. As a result, the implanted cells still survived in vivo 8 weeks after transplantation. They proliferated, integrated and differentiated in the injured cord. In the OPCs-treated rats, enhanced myelination in the lesioned area was observed and substantial improvement of motor function and nerve conduction was also recorded. Thus, this study provides strong evidence to support that transplantation of OPCs could improve myelination of injured cord and enhance functional recovery after contusive SCI.
- Subjects :
- medicine.medical_specialty
Pathology
Cord
Cellular differentiation
Neural Conduction
Oligodendrocyte progenitor
Rats, Sprague-Dawley
In vivo
Medicine
Animals
Spinal cord injury
Cells, Cultured
Myelin Sheath
Spinal Cord Injuries
General Environmental Science
business.industry
Cell Differentiation
Recovery of Function
medicine.disease
Functional recovery
Immunohistochemistry
Surgery
Rats
Transplantation
stomatognathic diseases
Disease Models, Animal
Oligodendroglia
nervous system
General Earth and Planetary Sciences
Female
business
Demyelinating Diseases
Stem Cell Transplantation
Subjects
Details
- ISSN :
- 18790267
- Volume :
- 43
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Injury
- Accession number :
- edsair.doi.dedup.....93e0399e86d25683d384cb9d58d9a777