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Function and regulation of chromatin insulators in dynamic genome organization

Authors :
Dahong Chen
Elissa P. Lei
Source :
Curr Opin Cell Biol
Publication Year :
2019

Abstract

Chromatin insulators are DNA-protein complexes that play a crucial role in regulating chromatin organization. Within the past two years, a plethora of genome-wide conformation capture studies have helped reveal that insulators are necessary for proper genome-wide organization of topologically associating domains, which are formed in a manner distinct from that of compartments. These studies have also provided novel insights into the mechanics of how CTCF/cohesin-dependent loops form in mammals, strongly supporting the loop extrusion model. In combination with single-cell imaging approaches in both Drosophila and mammals, the dynamics of insulator-mediated chromatin interactions are also coming to light. Insulator-dependent structures vary across individual cells and tissues, highlighting the need to study the regulation of insulators in particular temporal and spatial contexts throughout development.

Details

Language :
English
Database :
OpenAIRE
Journal :
Curr Opin Cell Biol
Accession number :
edsair.doi.dedup.....93d380a21c15dfc9879283c7eea489d7