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One tissue, two fates: molecular genetic events that underlie testis versus ovary development
- Source :
- Nature Reviews Genetics. 5:509-521
- Publication Year :
- 2004
- Publisher :
- Springer Science and Business Media LLC, 2004.
-
Abstract
- The pivotal point of vertebrate sex determination is the development of the gonad into a testis or ovary, which governs phenotypic sex through the production of hormones. The identification of Sry, the genetic switch that controls testis development in mammals, fuelled the race for the discovery of downstream pathways. Comparative analyses of XY versus XX gonadogenesis in both mouse and human genetic mutants have uncovered a burgeoning network of intra- and extra-cellular pathways. Here, we review the old and new players that are involved in the initial steps of testis and ovary development.
- Subjects :
- Male
medicine.medical_specialty
X Chromosome
Gonad
Ovary
Testicle
Biology
medicine.disease_cause
Y chromosome
Models, Biological
Mice
Sex Factors
Y Chromosome
Internal medicine
Testis
Genetics
medicine
Animals
Humans
Molecular Biology
Genetics (clinical)
X chromosome
Mice, Knockout
Mutation
Gene Expression Regulation, Developmental
Leydig Cells
Cell Differentiation
Sex Determination Processes
Phenotype
Cell biology
medicine.anatomical_structure
Endocrinology
Testis determining factor
Female
Cell Division
Subjects
Details
- ISSN :
- 14710064 and 14710056
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Nature Reviews Genetics
- Accession number :
- edsair.doi.dedup.....93ca1c1ada9e66202becfe1034728b42