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High-dose intravenous methylprednisolone in juvenile non-infectious uveitis: A retrospective analysis
- Source :
- Clinical immunology (Orlando, Fla.). 211
- Publication Year :
- 2019
-
Abstract
- Non-infectious uveitis is associated with visual impairment and blindness. Non-biologic treatment for non-infectious uveitis is not based on strong evidence. A retrospective chart review was conducted to investigate treatment response to high-dose intravenous methylprednisolone (IVMP) in children with non-infectious uveitis. Fifty-six patients (93 eyes affected) were included. In 29% uveitis was associated with juvenile idiopathic arthritis. Uveitis predominately affected the anterior segment, was bilateral and recurrent. Complications were common and included visual loss, synechiae, cataract and/or retinal lesions. Patients received up to 5 IVMP at monthly intervals. Visual acuity improved at 3 and 6 months. Anterior chamber cells, synechiae, keratic precipitates, papillary and/or macular edema improved at 3 months. Children treated with ≥3 IVMP (vs 1 IVMP) experienced trends towards fewer relapses, fewer cataracts and less frequently required treatment with biologic agents. High-dose IVMP induce rapid improvement in children with non-infectious uveitis. Prospective randomized trials are required to confirm results.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Visual acuity
Adolescent
medicine.drug_class
Immunology
Anti-Inflammatory Agents
Arthritis
Methylprednisolone
law.invention
Uveitis
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
Cataracts
law
Adrenal Cortex Hormones
Ophthalmology
medicine
Immunology and Allergy
Humans
Child
Macular edema
Retrospective Studies
business.industry
medicine.disease
Arthritis, Juvenile
030104 developmental biology
Treatment Outcome
Child, Preschool
Corticosteroid
Administration, Intravenous
Female
medicine.symptom
business
030215 immunology
medicine.drug
Subjects
Details
- ISSN :
- 15217035
- Volume :
- 211
- Database :
- OpenAIRE
- Journal :
- Clinical immunology (Orlando, Fla.)
- Accession number :
- edsair.doi.dedup.....93c1eb9314dc1e09e820839cd7e6c1df