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Infection of dendritic cells by murine cytomegalovirus induces functional paralysis
- Source :
- Nature Immunology. 2:1077-1084
- Publication Year :
- 2001
- Publisher :
- Springer Science and Business Media LLC, 2001.
-
Abstract
- Cytomegalovirus (CMV), measles and HIV are the main human pathogens known to induce immunosuppression. Unlike measles and HIV, and despite the availability of a well studied animal model, little is known about the mechanisms that control CMV-induced immunosuppression. We hypothesized that dendritic cells (DCs), which are crucial in generating and maintaining immune responses, represent a target for CMV and that the transient, but profound, immunosuppression that accompanies CMV infection results from viral interference with DC functions. Here we show that DCs were permissive to murine CMV infection. In addition, DC infection prevented delivery of the signals required for T cell activation. Thus, CMV-mediated impairment of DC function may be crucial for virally induced immunosuppression and interleukin 2 is implicated as a key factor.
- Subjects :
- Lipopolysaccharides
Interleukin 2
medicine.medical_treatment
T cell
Immunology
Congenital cytomegalovirus infection
Cytomegalovirus
Biology
Lymphocyte Activation
Virus Replication
Immune tolerance
Immunocompromised Host
Mice
Immune system
Genes, Reporter
T-Lymphocyte Subsets
Immune Tolerance
medicine
Animals
Immunology and Allergy
Viral Interference
Mice, Inbred BALB C
Immunologic Deficiency Syndromes
virus diseases
Immunosuppression
Dendritic Cells
beta-Galactosidase
medicine.disease
Virology
Endocytosis
Specific Pathogen-Free Organisms
Mice, Inbred C57BL
medicine.anatomical_structure
Lac Operon
Viral replication
Cytomegalovirus Infections
medicine.drug
Subjects
Details
- ISSN :
- 15292916 and 15292908
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- Nature Immunology
- Accession number :
- edsair.doi.dedup.....93be42cb74a255f93422fcc36540c117