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Age-Related Increase in Food Spilling by Laboratory Mice May Lead to Significant Overestimation of Actual Food Consumption: Implications for Studies on Dietary Restriction, Metabolism, and Dose Calculations
- Source :
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publication Year :
- 2012
- Publisher :
- Oxford University Press (OUP), 2012.
-
Abstract
- It is widely accepted that food consumption in humans declines with advanced age; however, data from mice remain controversial. Based on our previous observation that mice spill a considerable amount of food while eating, we hypothesized that increased food spillage in old mice masks actual food intake. To investigate whether mice exhibit age-associated declines in food consumption, we evaluated the actual food consumption of C57BL/6 mice at various ages by measuring both the amount of food in the food receptacle and the amount dropped to the cage bottom during feeding. We found that old mice dropped significantly more food (36% ± 8%) than young mice (18% ± 5%), which led to overestimations of food consumption, particularly in old mice. Although actual food consumption decreased in very old mice, food intake per body weight did not significantly change. These findings suggest that caution should be taken to accurately quantify food consumption by aged animals.
- Subjects :
- Male
Aging
Food intake
Dose calculation
Diet therapy
Food consumption
Body weight
Article
Eating
Mice
03 medical and health sciences
0302 clinical medicine
Animal science
Age related
Animals
Humans
Medicine
Food science
Animal Husbandry
C57BL/6 mice
030304 developmental biology
2. Zero hunger
0303 health sciences
business.industry
Body Weight
digestive, oral, and skin physiology
Metabolism
Animal husbandry
Mice, Inbred C57BL
Motor Skills
Models, Animal
Geriatrics and Gerontology
business
Food spillage
030217 neurology & neurosurgery
Diet Therapy
Subjects
Details
- ISSN :
- 1758535X and 10795006
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Accession number :
- edsair.doi.dedup.....93b80cb635e9d6203b3203e7dbb4707d