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The N-type and L-type calcium channel blocker cilnidipine suppresses renal injury in Dahl rats fed a high-salt diet
- Source :
- Heart and vessels. 25(6)
- Publication Year :
- 2009
-
Abstract
- The aims of the present study were to compare the effects of cilnidipine [L-type/N-type calcium channel blocker (CCB)] and amlodipine (L-type CCB) alone or in combination with the angiotensin II receptor blocker (ARB), valsartan, on blood pressure (BP), kidney function in Dahl salt-sensitive (DS) rats. DS rats fed a high-salt diet were divided into six groups; control (n = 13), two CCB (cilnidipine or amlodipine) groups at 1 mg/kg/day (n = 10), ARB (valsartan) at 10 mg/kg/day (n = 12), cilnidipine + valsartan (CV, n = 12), and amlodipine + valsartan (AV, n = 12). BPs were lower in the combination therapy groups than in those given either drug alone, but only CV inhibited the increase in urinary albumin excretion (UAE) and lowered the glomerular sclerosis score. In addition, AV elevated plasma renin activity and the angiotensin II concentration, and thus failed to inhibit increases in UAE and to lower glomerular sclerosis score. In conclusion, combination therapy with CCB and ARB decreases BP more effectively than either drug alone. When used in combination with valsartan, cilnidipine is more effective than amlodipine for preventing kidney injury.
- Subjects :
- Male
medicine.medical_specialty
Angiotensin receptor
Dihydropyridines
Time Factors
Calcium Channels, L-Type
medicine.drug_class
Renal function
Tetrazoles
Blood Pressure
Calcium channel blocker
Pharmacology
Kidney
Rats, Sprague-Dawley
Calcium Channels, N-Type
Glomerulonephritis
Internal medicine
medicine
Albuminuria
Animals
L-type calcium channel
Amlodipine
Sodium Chloride, Dietary
Antihypertensive Agents
Rats, Inbred Dahl
business.industry
Valine
Organ Size
Cilnidipine
Calcium Channel Blockers
Angiotensin II
Rats
Disease Models, Animal
Endocrinology
Valsartan
Hypertension
Drug Therapy, Combination
Kidney Diseases
Cardiology and Cardiovascular Medicine
business
Angiotensin II Type 1 Receptor Blockers
Biomarkers
medicine.drug
Subjects
Details
- ISSN :
- 16152573
- Volume :
- 25
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Heart and vessels
- Accession number :
- edsair.doi.dedup.....93a987f03db5a1ca3cb3825b2c51a07b