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The Anti-Proliferative Activity of Coordination Compound-Based ZnO Nanoparticles as a Promising Agent Against Triple Negative Breast Cancer Cells
- Source :
- International Journal of Nanomedicine, International Journal of Nanomedicine. 2021, vol. 16, issue 1, p. 4431-4449.
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Abstract
- Hana Stepankova,1,2 Marcin Swiatkowski,3 Rafal Kruszynski,3 Pavel Svec,1 Hana Michalkova,1 Vendula Smolikova,1,2 Andrea Ridoskova,1,4 Zbynek Splichal,1,2 Petr Michalek,1,2 Lukas Richtera,1,2 Pavel Kopel,5 Vojtech Adam,1,2 Zbynek Heger,1,2 Simona Rex1,2 1Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czechia; 2Central European Institute of Technology, Brno University of Technology, Brno, Czechia; 3Institute of General and Ecological Chemistry, Lodz University of Technology, Lodz, Poland; 4Central European Institute of Technology, Mendel University in Brno, Brno, Czechia; 5Department of Inorganic Chemistry, Faculty of Science, Palacky University, Olomouc, CzechiaCorrespondence: Simona RexDepartment of Chemistry and Biochemistry, Mendel University in Brno, Brno, CzechiaTel +420-5-4513-3350Fax +425-5-4521-2044Email simona.rex@mendelu.czPurpose: The present study deals with the in vitro evaluation of the potential use of coordination compound-based zinc oxide (ZnO) nanoparticles (NPs) for the treatment of triple negative breast cancer cells (TNBrCa). As BrCa is one of the most prevalent cancer types and TNBrCa treatment is difficult due to poor prognosis and a high metastasis rate, finding a more reliable treatment option should be of the utmost interest.Methods: Prepared by reacting zinc carboxylates (formate, acetate, propionate, butyrate, isobutyrate, valerate) and hexamethylenetetramine, 4 distinct coordination compounds were further subjected to two modes of conversion into ZnO NPs â ultrasonication with oleic acid or heating of pure precursors in an air atmosphere. After detailed characterization, the resulting ZnO NPs were subjected to in vitro testing of cytotoxicity toward TNBrCa and normal breast epithelial cells. Further, their biocompatibility was evaluated.Results: The resulting ZnO NPs provide distinct morphological features, size, biocompatibility, and selective cytotoxicity toward TNBrCa cells. They internalize into two types of TNBrCa cells and imbalance their redox homeostasis, influencing their metabolism, morphology, and ultimately leading to their death via apoptosis or necrosis.Conclusion: The crucial properties of ZnO NPs seem to be their morphology, size, and zinc content. The ZnO NPs with the most preferential values of all three properties show great promise for a future potential use in the therapy of TNBrCa.Keywords: carboxylate, hexamethylenetetramine, nanoparticles, redox homeostasis imbalance, triple negative breast cancer, zinc oxide coordination compounds
- Subjects :
- carboxylate
Biocompatibility
Sonication
Biophysics
Pharmaceutical Science
chemistry.chemical_element
Nanoparticle
Antineoplastic Agents
Apoptosis
Triple Negative Breast Neoplasms
Bioengineering
Zinc
Butyrate
zinc oxide coordination compounds
Valerate
Biomaterials
redox homeostasis imbalance
International Journal of Nanomedicine
Cell Line, Tumor
Drug Discovery
Humans
Cytotoxicity
Cell Proliferation
Original Research
chemistry.chemical_classification
Chemistry
Organic Chemistry
General Medicine
Combinatorial chemistry
hexamethylenetetramine
In vitro
triple negative breast cancer
nanoparticles
Zinc Oxide
Subjects
Details
- Language :
- English
- ISSN :
- 11782013
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- International Journal of Nanomedicine
- Accession number :
- edsair.doi.dedup.....93a311944441d591964fded9368db2b0
- Full Text :
- https://doi.org/10.2147/ijn.s304902