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The Microbial Opsin Family of Optogenetic Tools
- Source :
- Cell. 147(7):1446-1457
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- The capture and utilization of light is an exquisitely evolved process. The single-component microbial opsins, although more limited than multicomponent cascades in processing, display unparalleled compactness and speed. Recent advances in understanding microbial opsins have been driven by molecular engineering for optogenetics and by comparative genomics. Here we provide a Primer on these light-activated ion channels and pumps, describe a group of opsins bridging prior categories, and explore the convergence of molecular engineering and genomic discovery for the utilization and understanding of these remarkable molecular machines.
- Subjects :
- Models, Molecular
Comparative genomics
Genetics
Opsin
Fungal protein
Opsins
Biochemistry, Genetics and Molecular Biology(all)
Molecular Sequence Data
Light sensing
Computational biology
Biology
Optogenetics
Protein Engineering
Article
General Biochemistry, Genetics and Molecular Biology
Molecular machine
Molecular engineering
Fungal Proteins
Bacterial protein
Bacterial Proteins
Animals
Humans
Amino Acid Sequence
sense organs
Phylogeny
Subjects
Details
- ISSN :
- 00928674
- Volume :
- 147
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Cell
- Accession number :
- edsair.doi.dedup.....93923f75f852b3395f8ff189ff8324d8
- Full Text :
- https://doi.org/10.1016/j.cell.2011.12.004