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Molecular subtypes of gastrointestinal stromal tumors and their prognostic and therapeutic implications
- Source :
- Future Oncology, Future Oncology, 13, 1, pp. 93-107, Future Oncology, 13, 93-107
- Publication Year :
- 2017
-
Abstract
- Contains fulltext : 177634.pdf (Publisher’s version ) (Open Access) Gastrointestinal stromal tumors (GISTs) are composed of various molecular subtypes, with differing prognostic and predictive relevance. Previously, tumors lacking mutations in the KIT and PDGFRA genes have been designated as 'wild-type' GISTs; however, they represent a heterogeneous group currently undergoing further subclassification. Primary and secondary resistance to imatinib poses a significant clinical challenge, therefore ongoing research is trying to evaluate mechanisms to overcome resistance. Thorough understanding of the prognostic and predictive relevance of different genetic subtypes of GIST can guide clinical decision-making both in the adjuvant and the metastatic setting. Further work is required to identify tailored therapies for specific subgroups of GISTs wild-type for KIT and PDGFRA mutations and to identify predictive factors of resistance to currently approved systemic therapies.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Stromal cell
Genotype
Gastrointestinal Stromal Tumors
Pfgfra
Clinical Decision-Making
PDGFRA
03 medical and health sciences
0302 clinical medicine
Clinical decision making
Internal medicine
Gene Duplication
Gene duplication
medicine
Biomarkers, Tumor
Animals
Humans
Sdh deficiency
neoplasms
Sequence Deletion
Gist
Heterogeneous group
GiST
business.industry
'wild-type' gist
Imatinib
Kit
General Medicine
Molecular subgroups
Prognosis
digestive system diseases
Braf
Proto-Oncogene Proteins c-kit
030104 developmental biology
Nf-1
030220 oncology & carcinogenesis
Immunology
business
medicine.drug
Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Subjects
Details
- Language :
- English
- ISSN :
- 14796694
- Database :
- OpenAIRE
- Journal :
- Future Oncology, Future Oncology, 13, 1, pp. 93-107, Future Oncology, 13, 93-107
- Accession number :
- edsair.doi.dedup.....938268e85d83916c77c1c4ad32be4179