Influence of some sympathomimetic amines on the experimental gastric ulcers in rats

In reserpine-induced ulcers in rats, the centrally acting sympathomimetic amines (amphetamine, mephentermine and ephedrine) produced a significant protection. Only amphetamine had a beneficial effect in restraint ulcers. Tyramine, a preponderant peripherally acting sympathomimetic amine, was inefficient in both experimental models. It is suggested that the protective activity is due to the influence of these amines on the adrenergic structures, mainly at central level.