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Highly regioselective control of 1,2-addition of organolithiums to α,β-unsaturated compounds promoted by lithium bromide in 2-methyltetrahydrofuran: a facile and eco-friendly access to allylic alcohols and amines
- Source :
- Tetrahedron. 67:2670-2675
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Very high regioselective 1,2-addition of organolithiums to α,β-unsaturated carbonyl-like compounds (ketones, aldehydes, and imines) in the presence of LiBr was achieved by carrying out reactions in the sustainable solvent 2-methyltetrahydrofuran. Excellent yields (in isolated product) of allylic alcohols and allylic amines were recovered under a simple experimental procedure at 0 °C.
Details
- ISSN :
- 00404020
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Tetrahedron
- Accession number :
- edsair.doi.dedup.....9368f15fca800ed771a4928acd497dab