Back to Search
Start Over
Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis
- Source :
- Chen, Y, Doughman, Y, Gu, S, Jarrell, A, Aota, S, Cvekl, A, Watanabe, M, Dunwoodie, S L, Johnson, R S, van Heyningen, V, Kleinjan, D A, Beebe, D C & Yang, Y-C 2008, ' Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis ', Development, vol. 135, no. 17, pp. 2939-48 . https://doi.org/10.1242/dev.021097
- Publication Year :
- 2008
-
Abstract
- Cited2 is a transcriptional modulator with pivotal roles in different biological processes. Cited2-deficient mouse embryos manifested two major defects in the developing eye. An abnormal corneal-lenticular stalk was characteristic of Cited2-/- developing eyes, a feature reminiscent of Peters' anomaly, which can be rescued by increased Pax6 gene dosage in Cited2-/- embryonic eyes. In addition, the hyaloid vascular system showed hyaloid hypercellularity consisting of aberrant vasculature, which might be correlated with increased VEGF expression in the lens. Deletion of Hif1a (which encodes HIF-1α) in Cited2-/- lens specifically eliminated the excessive accumulation of cellular mass and aberrant vasculature in the developing vitreous without affecting the corneal-lenticular stalk phenotype. These in vivo data demonstrate for the first time dual functions for Cited2:one upstream of, or together with, Pax6 in lens morphogenesis; and another in the normal formation of the hyaloid vasculature through its negative modulation of HIF-1 signaling. Taken together, our study provides novel mechanistic revelation for lens morphogenesis and hyaloid vasculature formation and hence might offer new insights into the etiology of Peters'anomaly and ocular hypervascularity.
- Subjects :
- genetic structures
PAX6 Transcription Factor
Morphogenesis
Biology
Article
Cornea
Mice
Lens, Crystalline
medicine
Animals
Paired Box Transcription Factors
Eye Proteins
Molecular Biology
Cell Proliferation
Homeodomain Proteins
Cell Death
Integrases
Gene Expression Regulation, Developmental
Anatomy
Hypervascularity
Hypoxia-Inducible Factor 1, alpha Subunit
Embryonic stem cell
Phenotype
eye diseases
Cell biology
Repressor Proteins
Vitreous Body
medicine.anatomical_structure
HIF1A
Lens (anatomy)
Trans-Activators
PAX6
sense organs
Gene Deletion
Developmental Biology
Signal Transduction
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Chen, Y, Doughman, Y, Gu, S, Jarrell, A, Aota, S, Cvekl, A, Watanabe, M, Dunwoodie, S L, Johnson, R S, van Heyningen, V, Kleinjan, D A, Beebe, D C & Yang, Y-C 2008, ' Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis ', Development, vol. 135, no. 17, pp. 2939-48 . https://doi.org/10.1242/dev.021097
- Accession number :
- edsair.doi.dedup.....935eae7a75ce39643b4afebffcb58bbc
- Full Text :
- https://doi.org/10.1242/dev.021097