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Antitumoral Drug: Loaded Hybrid Nanocapsules Based on Chitosan with Potential Effects in Breast Cancer Therapy
- Source :
- International Journal of Molecular Sciences, Volume 21, Issue 16, International Journal of Molecular Sciences, Vol 21, Iss 5659, p 5659 (2020)
- Publication Year :
- 2020
-
Abstract
- Cancer remains one of the world&rsquo<br />s most devastating diseases and is responsible for more than 20% of all deaths. It is defined as uncontrolled proliferation of cells and spreads rapidly to healthy tissue. Controlled drug delivery systems offers great opportunities for the development of new non-invasive strategies for the treatment of cancers. The main advantage of these systems is their capacity to accumulate in tumors via enhanced permeability and retention effects. In the present study, an innovative hybrid drug delivery system based on nanocapsules obtained from the interfacial condensation between chitosan and poly(N-vinyl pyrrolidone-alt-itaconic anhydride) and containing both magnetic nanoparticles and an antitumoral drug was developed in order to improve the efficiency of the antitumoral treatment. Using dynamic light scattering, it was observed that the mean diameter of these hybrid nanocapsules was in the range of 43 to 142 nm. SEM confirmed their nanometric size and their well-defined spherical shape. These nanocapsules allowed the encapsulation of an increased amount of 5-fluorouracil and provided controlled drug release. In vitro studies have revealed that these drug-loaded hybrid nanocapsules were able to induce a cytostatic effect on breast carcinoma MCF-7 cell lines (Human Caucasian breast adenocarcinoma - HTB-22) comparable to that of the free drug.
- Subjects :
- 02 engineering and technology
01 natural sciences
Chitosan
lcsh:Chemistry
chemistry.chemical_compound
Spectroscopy, Fourier Transform Infrared
5-fluorouracil
breast carcinoma
antitumoral therapy
Magnetite Nanoparticles
lcsh:QH301-705.5
smart polymers
Spectroscopy
media_common
Temperature
General Medicine
021001 nanoscience & nanotechnology
Computer Science Applications
Drug delivery
Thermogravimetry
MCF-7 Cells
Female
Fluorouracil
0210 nano-technology
Breast carcinoma
Drug
Cell Survival
media_common.quotation_subject
Static Electricity
Antineoplastic Agents
Breast Neoplasms
010402 general chemistry
Smart polymer
Catalysis
Nanocapsules
Article
Inorganic Chemistry
Breast cancer
medicine
Humans
Physical and Theoretical Chemistry
Particle Size
Molecular Biology
Organic Chemistry
medicine.disease
In vitro
hybrid nanocapsules
0104 chemical sciences
Drug Liberation
Kinetics
chemistry
lcsh:Biology (General)
lcsh:QD1-999
Cancer research
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 21
- Issue :
- 16
- Database :
- OpenAIRE
- Journal :
- International journal of molecular sciences
- Accession number :
- edsair.doi.dedup.....935db5cf7ba2251c5a6cb197033afe60