Back to Search
Start Over
Panax ginseng improves glucose metabolism in streptozotocin-induced diabetic rats through 5' adenosine monophosphate kinase up-regulation
- Source :
- Saudi Journal of Biological Sciences, Vol 26, Iss 7, Pp 1436-1441 (2019), Saudi Journal of Biological Sciences
- Publication Year :
- 2018
-
Abstract
- 5′ AMP-activated protein kinase (AMPK), insulin receptors and transporters are distorted in diabetes mellitus. In this study, the effect of Panax ginseng was assessed on glucose manipulating enzymes activities and gene expression of AMPK, IRA and GLUT2 in streptozotocin-induced diabetic male rats. Forty male albino rats were randomly divided to four groups 10 rats of each, group I, normal control group (received saline orally); group II, normal rats received 200 mg/kg of Panax ginseng orally; group III, Streptozotocin (STZ) –induced diabetic rats and group IV, STZ-induced diabetic rats received 200 mg/kg of Panax ginseng orally. The duration of experiment was 30 days. Results showed the ability of Panax ginseng to induce a significant decrease in the blood glucose and increase in the serum insulin levels, hepatic glucokinase (GK), and glycogen synthase (GS) activities with a modulation of lipid profile besides high expression levels of AMPK, insulin receptor A (IRA), glucose transporting protein-2 (GLUT-2) in liver of diabetic rats. In conclusion, the obtained results point to the ability of Panax ginseng to improve the glucose metabolism in diabetic models. Keywords: AMPK, Diabetes mellitus, Ginseng, GLUT2, Insulin
- Subjects :
- AMPK
medicine.medical_specialty
medicine.medical_treatment
Article
Ginseng
Diabetes mellitus
Internal medicine
medicine
Insulin
Glycogen synthase
lcsh:QH301-705.5
biology
Glucokinase
business.industry
medicine.disease
Insulin receptor
Endocrinology
lcsh:Biology (General)
biology.protein
GLUT2
General Agricultural and Biological Sciences
business
Subjects
Details
- ISSN :
- 1319562X
- Volume :
- 26
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Saudi journal of biological sciences
- Accession number :
- edsair.doi.dedup.....93529c9036a54866b0c86b31c520d27c