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Hippocampal Pyramidal Cell Orientation in Schizophrenia
- Source :
- Archives of General Psychiatry. 44:1094
- Publication Year :
- 1987
- Publisher :
- American Medical Association (AMA), 1987.
-
Abstract
- • The finding of marked disorganization of the hippocampal pyramidal cell layer in the brains of schizophrenic patients has recently been reported. The present study was undertaken to determine whether similar abnormalities could be found in the brains of a population of schizophrenic patients, most of whom were never exposed to neuroleptics. Though statistical analysis of 2808 pyramidal cells failed to reveal significantly greater disorganization in a group of seven alleged schizophrenic brains than in brains of age-matched, nonpsychotic controls, the data suggest a relationship between the degree of pyramidal cell disarray and the severity of behavioral impairment due to psychosis. The implications and pitfalls in interpreting these findings are discussed.
- Subjects :
- Adult
Male
Psychosis
Population
Central nervous system
Pain
Rhinencephalon
Hippocampus
Hippocampal formation
Arts and Humanities (miscellaneous)
medicine
Humans
education
Aged
Neurons
education.field_of_study
Schizophrenia, Paranoid
Schizophrenia, Catatonic
Schizophrenia, Disorganized
food and beverages
Parkinson Disease
Middle Aged
medicine.disease
Psychiatry and Mental health
medicine.anatomical_structure
Schizophrenia
Female
Schizophrenic Psychology
Pyramidal cell
Psychology
Neuroscience
Subjects
Details
- ISSN :
- 0003990X
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Archives of General Psychiatry
- Accession number :
- edsair.doi.dedup.....934dc8d2a442b944158cfb9002f60093