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Multifunctional Iron Bound Lactoferrin and Nanomedicinal Approaches to Enhance Its Bioactive Functions
- Source :
- Molecules, Molecules, Vol 20, Iss 6, Pp 9703-9731 (2015)
- Publication Year :
- 2015
- Publisher :
- MDPI AG, 2015.
-
Abstract
- Lactoferrin (Lf), an iron-binding protein from the transferr in family has been reported to have numerous functions. Even though Lf was first isolated from milk, it is also found in most exocrine secretions and in the secondary granules of neutrophils. Antimicrobial and anti-inflammatory activity reports on lactoferrin identified its significance in host defense against infection and extreme inflammation. Anticarcinogenic reports on lactoferrin make this protein even more valuable. This review is focused on the structural configuration of iron-containing and iron-free forms of lactoferrin obtained from different sources such as goat, camel and bovine. Apart for emphasizing on the specific beneficial properties of lactoferrin from each of these sources, the general antimicrobial, immunomodulatory and anticancer activities of lactoferrin are discussed here. Implementation of nanomedicinial strategies that enhance the bioactive function of lactoferrin are also discussed, along with information on lactoferrin in clinical trials. Refereed/Peer-reviewed
- Subjects :
- Camelus
camel
Neutrophils
Iron
Anti-Inflammatory Agents
Pharmaceutical Science
Antineoplastic Agents
Review
Iron Chelating Agents
Analytical Chemistry
Microbiology
lcsh:QD241-441
Exocrine secretion
fluids and secretions
lcsh:Organic chemistry
Anti-Infective Agents
Neoplasms
Drug Discovery
Animals
Humans
cancer
Physical and Theoretical Chemistry
Inflammation
chemistry.chemical_classification
Clinical Trials as Topic
biology
Lactoferrin
Goats
bovine
Organic Chemistry
food and beverages
Antimicrobial
immunity
Immunity, Innate
lactoferrin
stomatognathic diseases
chemistry
Biochemistry
Chemistry (miscellaneous)
Transferrin
biology.protein
Molecular Medicine
Cattle
nanoparticles
Function (biology)
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....9346995d03600807874789b4411c9ab3