Back to Search
Start Over
Risk of stroke in cancer survivors using a propensity score-matched cohort analysis
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Little is known about the risk of cerebrovascular disease in cancer survivors. We aimed to assess the association between incident cancer and the subsequent risk of stroke using a large-scale, population-based prospective study. 74,530 Japanese aged between 40 and 69 years at baseline study were matched by the status of cancer diagnosis during follow-up using propensity score nearest-neighbor matching with allowance for replacement. A total of 2242 strokes were reported during 557,885 person-years of follow-up. Associations between incident cancer and the subsequent risk of all strokes, cerebral infarction, and intracerebral hemorrhage were assessed using a Cox proportional hazards model stratified on the propensity score-matched pairs. No significant association was observed between the status of cancer diagnosis of all types, gastric, colorectal and lung cancer, and subsequent occurrence of all strokes, cerebral infarction, and intracerebral hemorrhage. However, analysis by discrete time periods suggested an elevated risk in cancer patients for one to three months after a cancer diagnosis in all stroke (HR, 2.24; 95% CI, 1.06, 4.74) and cerebral infarction (HR, 2.62; 95% CI, 1.05, 6.53). This prospective cohort study found no association between the status of cancer diagnosis and the subsequent occurrence of all strokes and its subtypes during the entire follow-up period but suggested an increase in stroke risk during the active phase of malignancy.
- Subjects :
- Adult
Male
medicine.medical_specialty
Science
Population
030204 cardiovascular system & hematology
Article
03 medical and health sciences
0302 clinical medicine
Cancer Survivors
Neoplasms
Internal medicine
medicine
Humans
Prospective Studies
cardiovascular diseases
Prospective cohort study
education
Stroke
Cancer
Aged
Cerebral Hemorrhage
Intracerebral hemorrhage
education.field_of_study
Multidisciplinary
Cerebral infarction
Proportional hazards model
business.industry
Cerebral Infarction
Middle Aged
medicine.disease
Oncology
030220 oncology & carcinogenesis
Propensity score matching
Medicine
Female
business
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....934456da643a96e67011017bdb27ed43