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Gene expression of the constant region of the heavy chain of immunoglobulin G (IgG CRHC) is down-regulated in human decidua in association with preeclampsia
- Source :
- Journal of reproductive immunology. 68(1-2)
- Publication Year :
- 2005
-
Abstract
- An aberrant interaction at the maternal/fetal interface between the genetically distinct fetal trophoblast cells and cells of the maternal decidua has been proposed as an initiating factor in one of the major complications of human pregnancy, preeclampsia. Biochemical and epidemiological studies suggest that the immune system plays an important role in preeclampsia. Thus, the aim of this study was to determine the decidual gene expression status in preeclampsia of one of the key components of the adaptive immune system. Total RNA was extracted from decidua collected from women with normal pregnancies and those complicated by preeclampsia. Reverse Northern analysis was performed on 72 cDNAs from human decidua and differentially expressed genes identified were analysed further using semi-quantitative RT-PCR and Northern blot analysis. Expression of the gene encoding the constant region of the heavy chain of immunoglobulin G (IgG CRHC) was shown to be down-regulated in association with preeclampsia. These data support the hypothesis that immune maladaptation may play an important role in the pathogenesis of preeclampsia.
- Subjects :
- Immunoglobulin gamma-Chains
Immunology
Down-Regulation
Immunoglobulin G
Preeclampsia
Immune system
Pre-Eclampsia
Pregnancy
medicine
Decidua
Immunology and Allergy
Humans
Northern blot
reproductive and urinary physiology
biology
Obstetrics and Gynecology
Trophoblast
medicine.disease
Acquired immune system
female genital diseases and pregnancy complications
medicine.anatomical_structure
Reproductive Medicine
embryonic structures
biology.protein
Female
Antibody
Subjects
Details
- ISSN :
- 01650378
- Volume :
- 68
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Journal of reproductive immunology
- Accession number :
- edsair.doi.dedup.....933e04f6800d587daa3f6342ec406999