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Low-intensity treadmill exercise protects cognitive impairment by enhancing cerebellar mitochondrial calcium retention capacity in a rat model of chronic cerebral hypoperfusion
- Source :
- Journal of Exercise Rehabilitation
- Publication Year :
- 2021
- Publisher :
- Korean Society of Exercise Rehabilitation, 2021.
-
Abstract
- Chronic cerebral hypoperfusion (CCH) is caused by reduced blood flow to the brain representing gradually cognitive impairment. CCH induces mitochondrial dysfunction and neuronal cell death in the brain. Exercise is known to have a neuroprotective effect on brain damage and cognitive dysfunction. This study aimed to clarify the neuroprotective effect of low-intensity treadmill exercise (LITE) by enhancing cerebellar mitochondrial calcium retention capacity in an animal model of CCH. Wistar rats were divided into the sham group, the bilateral common carotid arteries occlusion (BCCAO) group, and the BCCAO and treadmill exercise (BCCAO+Ex) group. BCCAO+Ex group engaged the LITE on a treadmill for 30 min once a day for 8 weeks before the BCCAO surgery to investigate the protective effect of LITE on cognitive impairment. CCH induced by BCCAO resulted in mitochondrial dysfunction in the cerebellum, including impaired calcium homeostasis. CCH also decreased cerebellar Purkinje cells including of calbindin D28k and parvalbumin, resulting in cognitive impairment. The impairment of mitochondrial function, loss of cerebellar Purkinje cells, and cognitive dysfunction ameliorated by exercise. The present study showed that LITE hindered the deficit of spatial working memory and loss of Purkinje cell in the cerebellum induced by CCH. We confirmed that the protective effect of LITE on Purkinje cell by enhanced the mitochondrial calcium retention capacity. We suggest that LITE may protect against cognitive impairment, and further studies are needed to develop the intervention for patients who suffered from CCH.
- Subjects :
- medicine.medical_specialty
Cerebellum
endocrine system
Cerebral hypoperfusion Cognition
Purkinje cell
Physical Therapy, Sports Therapy and Rehabilitation
Brain damage
Neuroprotection
Internal medicine
medicine
Orthopedics and Sports Medicine
Treadmill
Exercise
Calcium metabolism
biology
business.industry
Mitochondria
Endocrinology
medicine.anatomical_structure
Cerebral blood flow
biology.protein
Original Article
Calcium
medicine.symptom
business
Parvalbumin
Subjects
Details
- Language :
- English
- ISSN :
- 22881778 and 2288176X
- Volume :
- 17
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of Exercise Rehabilitation
- Accession number :
- edsair.doi.dedup.....93317eca669da9738ab3e362b13e9a52