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Serum folate, vitamin B(12) and cognitive impairment in Chilean older adults
- Source :
- Public Health Nutr
- Publication Year :
- 2015
- Publisher :
- Cambridge University Press, 2015.
-
Abstract
- ObjectiveTo analyse the relationship between serum folate (SF), vitamin B12 and impaired cognitive function in the Chilean elderly.DesignWe analysed the relationships between impaired cognitive function and age, SF (µg/l) and vitamin B12 (pg/ml) with Student’s t test, as well as between impaired cognitive function and gender, educational level, residence area, diabetes and hypertension with the χ2 test. Multiple logistic regressions with interactions were estimated to assess the impact of SF on impaired cognitive function according to these methods.SettingChile.SubjectsOlder adults (>65 years, n 1051), drawn from representative households of a national prevalence study, assessed using the Modified Mini Mental Status Examination (MMMSE). Individuals with altered MMMSE scores (≤13 points) were sequentially assessed using the Pfeffer Functional Activities Questionnaire (PFAQ).ResultsMultivariate models using the MMMSE demonstrated an increased risk of impaired cognitive function for seniors who had hypertension, diabetes and higher vitamin B12 levels. SF and its square (SF2) were statistically significant, indicating that this predictor of impaired cognitive function displays a U-shaped distribution. The interaction between SF and vitamin B12 was not statistically significant. Models using the MMMSE plus PFAQ suggested that urban residence decreased the risk of impaired cognitive function, whereas male gender, older age, vitamin B12 levels and hypertension increased this risk. The variables SF and SF2 and the SF × vitamin B12 interaction were statistically significant (P12 levels. When SF was low, a one-unit increase in SF (1 µg/l) diminished the risk. When SF was elevated, a further increase in SF raised the risk, especially at low vitamin B12 levels.ConclusionsThe relationship between folate, vitamin B12 and impaired cognitive function warrants further study.
- Subjects :
- Gerontology
Male
medicine.medical_specialty
Urban Population
Medicine (miscellaneous)
Nutritional Status
Folic Acid Deficiency
Logistic regression
Serum folate
Cognition
Folic Acid
Sex Factors
Diabetes mellitus
Internal medicine
Surveys and Questionnaires
Activities of Daily Living
medicine
Humans
Vitamin B12
Chile
Cognitive impairment
Geriatric Assessment
Male gender
Aged
Nutrition and Dietetics
business.industry
Public Health, Environmental and Occupational Health
Age Factors
Vitamin B 12 Deficiency
medicine.disease
Functional Activities Questionnaire
Research Papers
Vitamin B 12
Cross-Sectional Studies
Nutrition Assessment
Hypertension
Vitamin B Complex
Female
business
Cognition Disorders
Subjects
Details
- Language :
- English
- ISSN :
- 13689800
- Database :
- OpenAIRE
- Journal :
- Public Health Nutr
- Accession number :
- edsair.doi.dedup.....932a1901baed5e67d61eaac82a0df2b9