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Didanosine but Not High Doses of Hydroxyurea Rescue Pigtail Macaque from a Lethal Dose of SIVsmmpbj14
- Source :
- AIDS Research and Human Retroviruses. 13:1083-1088
- Publication Year :
- 1997
- Publisher :
- Mary Ann Liebert Inc, 1997.
-
Abstract
- It has been previously reported that hydroxyurea (HU) displays anti-HIV-1 activity and potentiates the antiviral effects of didanosine (ddI) in vitro. To assess the antiviral efficacy of HU in an animal model, the effects of HU and ddI, either individually or as combination therapy, were tested in a model using infection of pigtail macaque with the acutely fatal variant SIV(smpbj14). At the high dosage used (100 mg/kg/day), HU monotherapy failed to protect the exposed animals from viral infection and death, which occurred within 10 days postinoculation. However, both of the ddI-treated animals (5 mg/kg/day) survived the SIV(smmpbj14) lethal dose and displayed a reduction in viral load (undetectable SIV RNA or p27gag) in the primary phase of infection. Of the animals treated with the combination of drugs, one died at day 18 after infection and failed to seroconvert to viral antigens. These data suggest that a high dose of HU monotherapy does not protect against death induced by SIV(mmpbj14). However, lower doses of HU as monotherapy or combination therapy deserve further evaluation for their therapeutic effects.
- Subjects :
- Combination therapy
Neutrophils
medicine.medical_treatment
Immunology
Simian Acquired Immunodeficiency Syndrome
Gene Products, gag
Cell Count
Antibodies, Viral
Virus Replication
medicine.disease_cause
Hydroxycarbamide
Virology
medicine
Animals
Hydroxyurea
Didanosine
Chemotherapy
biology
Lethal dose
virus diseases
Pigtail macaque
Simian immunodeficiency virus
biology.organism_classification
Infectious Diseases
Leukocytes, Mononuclear
Drug Therapy, Combination
Macaca nemestrina
Viral load
medicine.drug
Subjects
Details
- ISSN :
- 19318405 and 08892229
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- AIDS Research and Human Retroviruses
- Accession number :
- edsair.doi.dedup.....9325db223a984d337784918d24339c30