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Relationship between sex hormones and cognitive performance in men with substance use
- Source :
- Drug and Alcohol Dependence. 128:250-254
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- BACKGROUND: Hypogonadism is common with opiate-like drug use and may contribute to cognitive abnormalities. With the increasing epidemic of HIV and substance use (SU) worldwide, it is important to understand the impact of these conditions on cognition, which may affect quality of life and possibly decrease adherence to treatment. We hypothesized that men with SU, by virtue of hypogonadism secondary to HIV and/or SU, may demonstrate impaired cognition. METHODS: We recruited men aged 18-50 from a population of low income, inner-city individuals. Details of HIV and SU status, serum blood levels of total testosterone (TT), free testosterone (FT) and estradiol (E2) were assessed. All subjects were administered ten neuropsychological tests. RESULTS: Our sample consisted of 68 men (mean age: 43.2 years (SD 5.8), African Americans: 86.6%). The recruited population was primarily from low socioeconomic status and unemployed. The mean level of TT was 553.9ng/dL (SD 262.0), the mean level of FT was 69.5pg/mL (SD 34.8), mean E2 was 3.2pg/mL (SD 4.4). We found that 30.9% were hypogonadal and it was associated with higher SU. We observed some relationships between sex hormones and cognitive domains, however, after adjustment for age, drug use category, education, depression, HIV, there was no statistically significant correlation between cognitive performance and sex hormone levels. CONCLUSIONS: In this cross-sectional study of men with a high prevalence of SU and hypogonadism, endogenous levels of TT, FT or E2 were not related to cognitive performance. Other factors need to be identified which may contribute to poor cognitive function in the setting of SU. Language: en
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Urban Population
Substance-Related Disorders
Cross-sectional study
Population
Poison control
HIV Infections
Neuropsychological Tests
Toxicology
Mass Spectrometry
Article
Cognition
Sex hormone-binding globulin
Internal medicine
medicine
Humans
Testosterone
Pharmacology (medical)
Effects of sleep deprivation on cognitive performance
Psychiatry
education
Poverty
Pharmacology
Analysis of Variance
education.field_of_study
Estradiol
biology
business.industry
Hypogonadism
Neuropsychology
Testosterone (patch)
Middle Aged
Psychiatry and Mental health
Cross-Sectional Studies
biology.protein
business
Chromatography, Liquid
Subjects
Details
- ISSN :
- 03768716
- Volume :
- 128
- Database :
- OpenAIRE
- Journal :
- Drug and Alcohol Dependence
- Accession number :
- edsair.doi.dedup.....931e9e07b54b06d5ac2826ae05b7d200