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Short-term effects of a combined nutraceutical of insulin-sensitivity, lipid level and indexes of liver steatosis: a double-blind, randomized, cross-over clinical trial
- Source :
- Nutrition Journal
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Background: Overweight subjects easily develop alterations of the glucose and lipid metabolism and are exposed to an increased cardiometabolic risk. This condition is potentially reversible through the improvement of dietary and behavioural habits. However, a well-assembled nutraceutical would be a useful tool to better improve the metabolic parameters associated to overweight and insulin resistance. Methods: To evaluate the effect of a combined nutraceutical containing berberine, chlorogenic acid and tocotrienols, we performed a double blind, cross-over designed trial versus placebo, in 40 overweight subjects with mixed hyperlipidaemia. After the first 8 weeks of treatment (or placebo), patients were asked to observe a 2-week washout period, and they were then assigned to the alternative treatment for a further period of 8 weeks. Clinical and laboratory data associated to hyperlipidaemia and insulin resistance have been obtained at the baseline, at the end of the first treatment period, after the washout, and again after the second treatment period. Results: Both groups experienced a significant improvement of anthropometric and biochemical parameters versus baseline. However, total cholesterol, LDL cholesterol, triglycerides, non-HDL cholesterol, fasting insulin, HOMA-IR, GOT and Lipid Accumulation Product decreased more significantly in the nutraceutical group versus placebo. Conclusions: This combination seems to improve a large number of metabolic and liver parameters on the short-term in overweight subjects. Further studies are needed to confirm these observations on the middle- and long-term.
- Subjects :
- Adult
Male
medicine.medical_specialty
Berberine
Lipoproteins
Liver steatosis
Medicine (miscellaneous)
Hyperlipidemias
Clinical nutrition
Overweight
Placebo
Gastroenterology
Time
law.invention
chemistry.chemical_compound
Insulin resistance
Double-Blind Method
Randomized controlled trial
law
Internal medicine
medicine
Humans
Insulin
Lipoprotein
Aged
Insulin-sensitivity
Cross-Over Studies
Nutrition and Dietetics
Cholesterol
business.industry
Research
Tocotrienols
Chlorogenic acid
Middle Aged
medicine.disease
Lipids
Crossover study
Fatty Liver
Treatment Outcome
chemistry
Liver steatosi
Dietary Supplements
Female
lipids (amino acids, peptides, and proteins)
Nutraceutical
Insulin Resistance
medicine.symptom
business
Lipid Accumulation Product
Subjects
Details
- ISSN :
- 14752891
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Nutrition Journal
- Accession number :
- edsair.doi.dedup.....9314dc1057586be5fea43feb35aeddca