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Decaffeinated coffee prevents scopolamine-induced memory impairment in rats
Decaffeinated coffee prevents scopolamine-induced memory impairment in rats
- Source :
- Behavioural Brain Research. 245:113-119
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Introduction Several human studies have reported that coffee consumption improves cognitive performance. In the present study, we investigated whether instant decaffeinated coffee also ameliorates cognitive performance and attenuates the detrimental effects of scopolamine on memory. Methods Memory performance was evaluated in Morris water maze test and passive avoidance test. Instant decaffeinated coffee (p.o.) at 120 or 240 mg/kg in Sprague-Dawley rats, which is equivalent to approximately three or six cups of coffee, respectively, in a 60 kg human, was administered for two weeks. Results Oral gavage administration of instant decaffeinated coffee inhibited scopolamine-induced memory impairment, which was measured by Morris water maze test and passive avoidance test. Instant decaffeinated coffee suppressed scopolamine-mediated elevation of tumor necrosis factor-α (TNF-α) and stimulation of nuclear factor-κB (NF-κB) pathway (i.e., phosphorylation of IκBα and p65) in the rat hippocampus. Discussion These findings suggest that caffeine-free decaffeinated coffee may prevent memory impairment in human through the inhibition of NF-κB activation and subsequent TNF-α production.
- Subjects :
- Male
Blotting, Western
Scopolamine
Hippocampus
Morris water navigation task
Stimulation
Muscarinic Antagonists
Pharmacology
Decaffeinated coffee
Coffee
Developmental psychology
Rats, Sprague-Dawley
Behavioral Neuroscience
Caffeine
Avoidance Learning
medicine
Animals
Memory impairment
Effects of sleep deprivation on cognitive performance
Maze Learning
Brain Chemistry
Memory Disorders
Tumor Necrosis Factor-alpha
NF-kappa B
Actins
Rats
IκBα
Central Nervous System Stimulants
Psychology
medicine.drug
Subjects
Details
- ISSN :
- 01664328
- Volume :
- 245
- Database :
- OpenAIRE
- Journal :
- Behavioural Brain Research
- Accession number :
- edsair.doi.dedup.....93090aabe5a49570e2fa2244733b098c
- Full Text :
- https://doi.org/10.1016/j.bbr.2013.02.003