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Decaffeinated coffee prevents scopolamine-induced memory impairment in rats

Decaffeinated coffee prevents scopolamine-induced memory impairment in rats

Authors :
Jung-Hee Jang
Ki Won Lee
Hyong Joo Lee
Chang-Yul Kim
Young Jin Jang
Jiyoung Kim
Jaesung Shim
Source :
Behavioural Brain Research. 245:113-119
Publication Year :
2013
Publisher :
Elsevier BV, 2013.

Abstract

Introduction Several human studies have reported that coffee consumption improves cognitive performance. In the present study, we investigated whether instant decaffeinated coffee also ameliorates cognitive performance and attenuates the detrimental effects of scopolamine on memory. Methods Memory performance was evaluated in Morris water maze test and passive avoidance test. Instant decaffeinated coffee (p.o.) at 120 or 240 mg/kg in Sprague-Dawley rats, which is equivalent to approximately three or six cups of coffee, respectively, in a 60 kg human, was administered for two weeks. Results Oral gavage administration of instant decaffeinated coffee inhibited scopolamine-induced memory impairment, which was measured by Morris water maze test and passive avoidance test. Instant decaffeinated coffee suppressed scopolamine-mediated elevation of tumor necrosis factor-α (TNF-α) and stimulation of nuclear factor-κB (NF-κB) pathway (i.e., phosphorylation of IκBα and p65) in the rat hippocampus. Discussion These findings suggest that caffeine-free decaffeinated coffee may prevent memory impairment in human through the inhibition of NF-κB activation and subsequent TNF-α production.

Details

ISSN :
01664328
Volume :
245
Database :
OpenAIRE
Journal :
Behavioural Brain Research
Accession number :
edsair.doi.dedup.....93090aabe5a49570e2fa2244733b098c
Full Text :
https://doi.org/10.1016/j.bbr.2013.02.003