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A review on the Scorpaena plumieri fish venom and its bioactive compounds
- Source :
- The Journal of Venomous Animals and Toxins Including Tropical Diseases, Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 22, Article number: 35, Published: 19 JAN 2017, Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 22, Iss 0 (2017), Journal of Venomous Animals and Toxins including Tropical Diseases v.22 2016, The Journal of venomous animals and toxins including tropical diseases, Universidade Estadual Paulista (UNESP), instacron:UNESP
- Publication Year :
- 2016
- Publisher :
- BioMed Central, 2016.
-
Abstract
- The most poisonous fish species found along the Brazilian coast is the spotted scorpionfish Scorpaena plumieri. Though hardly ever life-threatening to humans, envenomation by S. plumieri can be quite hazardous, provoking extreme pain and imposing significant socioeconomic costs, as the victims may require days to weeks to recover from their injuries. In this review we will walk the reader through the biological features that distinguish this species as well as the current epidemiological knowledge related to the envenomation and its consequences. But above all, we will discuss the challenges involved in the biochemical characterization of the S. plumieri venom and its compounds, focusing then on the successful isolation and pharmacological analysis of some of the bioactive molecules responsible for the effects observed upon envenomation as well as on experimental models. Despite the achievement of considerable progress, much remains to be done, particularly in relation to the non-proteinaceous components of the venom. Therefore, further studies are necessary in order to provide a more complete picture of the venom’s chemical composition and physiological effects. Given that fish venoms remain considerably less studied when compared to terrestrial venoms, the exploration of their full potential opens a myriad of possibilities for the development of new drug leads and tools for elucidating the complex physiological processes.
- Subjects :
- 0301 basic medicine
lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962
Bioactive molecules
Fish species
Zoology
Venom
Review
Biology
Scorpionfish
Toxicology
03 medical and health sciences
lcsh:RA1190-1270
Scorpaena plumieri
lcsh:Zoology
C-type lectins
Sp-CTx
lcsh:QL1-991
Envenomation
lcsh:Toxicology. Poisons
Fish Venoms
030102 biochemistry & molecular biology
Sp-GP
Inflammatory response
Proteolytic activity
030104 developmental biology
Infectious Diseases
Fish
Cardiovascular activity
Animal Science and Zoology
Parasitology
Spotted scorpionfish
Plumieribetin
Scorpaena plumieri venom
Subjects
Details
- Language :
- English
- ISSN :
- 16789199
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- The Journal of Venomous Animals and Toxins Including Tropical Diseases
- Accession number :
- edsair.doi.dedup.....92faf36d8868790f03be332fdc715833