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Functional and antigenic properties of complement receptor type 2, CR2
- Source :
- The Journal of Experimental Medicine
- Publication Year :
- 1987
-
Abstract
- This is the first report demonstrating that C3d receptor (CR2) has functional activity in regulating complement cascade. Purified CR2 was examined for its cofactor activity in factor I-mediated cleavage of membrane-bound iC3b. CR2 plus C3b inactivator (I) released C3c from EA 125I-iC3b, and the release was inhibited when CR2 was preincubated with OKB7 monoclonal anti-CR2. Furthermore, immunoelectroblotting analysis showed crossreactivity of CR2 with 57H anti-CR1. These results indicate that CR2 has functional and antigenic similarity to CR1, thus providing a supporting evidence for placement of CR2 as a member of the recently defined gene family of C3- and C4-regulatory proteins composed of CR1, C4-binding protein, and factor H.
- Subjects :
- Paper
biology
Chemistry
Immunology
Collodion
chemical and pharmacologic phenomena
Complement receptor
Articles
Cross Reactions
Complement C3d
Epitope
Cofactor
Complement system
Receptors, Complement
Epitopes
Biochemistry
Cell surface receptor
biology.protein
Immunology and Allergy
Gene family
iC3b
Humans
Electrophoresis, Polyacrylamide Gel
Receptors, Complement 3d
Subjects
Details
- ISSN :
- 00221007
- Volume :
- 165
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- The Journal of experimental medicine
- Accession number :
- edsair.doi.dedup.....92f9f15e16ddab068c39dc9233643df1