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Nanocomposite-Strengthened Dissolving Microneedles for Improved Transdermal Delivery to Human Skin
- Source :
- Yan, L, Raphael, A P, Zhu, X, Wang, B, Chen, W, Tang, T, Deng, Y, Sant, H J, Zhu, G, Choy, K W, Gale, B K, Prow, T W & Chen, X 2014, ' Nanocomposite-Strengthened Dissolving Microneedles for Improved Transdermal Delivery to Human Skin ', Advanced Healthcare Materials, vol. 3, no. 4, pp. 555-564 . < http://onlinelibrary.wiley.com/doi/10.1002/adhm.201300312/epdf >
- Publication Year :
- 2014
-
Abstract
- Delivery of drugs and biomolecules into skin has significant advantages. To achieve this, herein, a nanomaterial-strengthened dissolving microneedle patch for transdermal delivery is reported. The patch comprises thousands of microneedles, which are composed of dissolving polymers, nanomaterials, and drug/biomolecules in their interior. With the addition of nanomaterials, the mechanical property of generally weak dissolving polymers can be dramatically improved without sacrificing dissolution rate within skin. In this experiments, layered double hydroxides (LDH) nanoparticles are incorporated into sodium carboxymethylcellulose (CMC) to form a nanocomposite. The results show that, by adding 5 wt% of LDH nanoparticles into CMC, the mechanical strength significantly increased. Small and densely packed CMC-LDH microneedles penetrate human and pig skin more reliably than pure CMC ones and attractively the nanocomposite-strengthened microneedles dissolve in skin and release payload within only 1 min. Finally, the application of using the nanocomposite-strengthened microneedle arrays is tested for in vivo vaccine delivery and the results show that significantly stronger antibody response could be induced when compared with subcutaneous injection. These data suggest that nanomaterials could be useful for fabricating densely packed and small polymer microneedles that have robust mechanical properties and rapid dissolution rates and therefore potential use in clinical applications. Refereed/Peer-reviewed
- Subjects :
- biomedical applications
Materials science
Microinjections
Ovalbumin
Swine
Materials Science
Biomedical Engineering
Pharmaceutical Science
Nanoparticle
Nanotechnology
Human skin
engineering.material
Administration, Cutaneous
Nanomaterials
Nanocomposites
Biomaterials
Drug Delivery Systems
Engineering
Hydroxides
Animals
Humans
Nanoscience & Nanotechnology
Dissolution
Engineering, Biomedical
Transdermal
chemistry.chemical_classification
Materials Science, Biomaterials
Nanocomposite
nanocomposite
Layered double hydroxides
Polymer
vaccine delivery
polymeric material
chemistry
Needles
Carboxymethylcellulose Sodium
engineering
Science & Technology - Other Topics
transdermal delivery
Biomedical engineering
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Yan, L, Raphael, A P, Zhu, X, Wang, B, Chen, W, Tang, T, Deng, Y, Sant, H J, Zhu, G, Choy, K W, Gale, B K, Prow, T W & Chen, X 2014, ' Nanocomposite-Strengthened Dissolving Microneedles for Improved Transdermal Delivery to Human Skin ', Advanced Healthcare Materials, vol. 3, no. 4, pp. 555-564 . < http://onlinelibrary.wiley.com/doi/10.1002/adhm.201300312/epdf >
- Accession number :
- edsair.doi.dedup.....92f0b982b505ea259369c96f7cde4760