Back to Search
Start Over
The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting
- Source :
- Nature Reviews Immunology. 17:60-75
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Patients with rheumatoid arthritis can be divided into two major subsets characterized by the presence versus absence of antibodies to citrullinated protein antigens (ACPAs) and of rheumatoid factor (RF). The antibody-positive subset of disease, also known as seropositive rheumatoid arthritis, constitutes approximately two-thirds of all cases of rheumatoid arthritis and generally has a more severe disease course. ACPAs and RF are often present in the blood long before any signs of joint inflammation, which suggests that the triggering of autoimmunity may occur at sites other than the joints (for example, in the lung). This Review summarizes recent progress in our understanding of this gradual disease development in seropositive patients. We also emphasize the implications of this new understanding for the development of preventive and therapeutic strategies. Similar temporal and spatial separation of immune triggering and clinical manifestations, with novel opportunities for early intervention, may also occur in other immune-mediated diseases.
- Subjects :
- musculoskeletal diseases
0301 basic medicine
History
Osteoimmunology
Arthritis
Disease
medicine.disease_cause
Autoantigens
Education
Autoimmunity
Arthritis, Rheumatoid
03 medical and health sciences
0302 clinical medicine
Immune system
Humans
Medicine
Rheumatoid factor
skin and connective tissue diseases
Autoantibodies
030203 arthritis & rheumatology
business.industry
Autoantibody
medicine.disease
Computer Science Applications
030104 developmental biology
Rheumatoid arthritis
Immunology
business
Subjects
Details
- ISSN :
- 14741741 and 14741733
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Nature Reviews Immunology
- Accession number :
- edsair.doi.dedup.....92da17c1a853dad58ee24239c5117fe4