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Stress and pain responses in rats lacking CCK1 receptors
- Source :
- Peptides. 27:1483-1489
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- CCK involvement in stress- and pain-responsiveness was examined by studying the beha- vior of infant (11-12-days-old) and adult OLETF rats that do not express CCK1 receptors. Infant odor- and texture-preferences were also assessed. We hypothesized that OLETF rats will show behavioral patterns similar to those previously observed after CCK1 antagonist administration. Rate of separation-induced ultrasonic vocalization was significantly greater in OLETF compared to controls, in two separate studies. Infant pups of the two strains did not differ in odor- and texture-preference tests. OLETF rats showed consistently longer hot- plate paw-lift (as infants, in two separate studies) and paw-lick (as adults) latencies. Summary: OLETF pups vocalized in isolation more than controls and showed relative hypoalgesic responses, evident also in adulthood, in concordance with the pharmacological literature.
- Subjects :
- Male
Pain Threshold
Aging
medicine.medical_specialty
Time Factors
Physiology
Pain
Neuropeptide
Body weight
Biochemistry
Cellular and Molecular Neuroscience
Endocrinology
Stress, Physiological
Internal medicine
Threshold of pain
medicine
Animals
Receptor
Pain Measurement
Cholecystokinin
Behavior, Animal
Body Weight
Antagonist
Rats
Pain responses
Odor
Odorants
Female
Receptors, Cholecystokinin
Psychology
Subjects
Details
- ISSN :
- 01969781
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Peptides
- Accession number :
- edsair.doi.dedup.....92d0eb84cb7b22210b9f6208d9e1c263