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Failure to modulate reward prediction errors in declarative learning with theta (6 Hz) frequency transcranial alternating current stimulation
- Source :
- PLoS ONE, PLoS ONE, Vol 15, Iss 12, p e0237829 (2020), PLOS ONE
- Publication Year :
- 2020
- Publisher :
- Public Library of Science, 2020.
-
Abstract
- Recent evidence suggests that reward prediction errors (RPEs) play an important role in declarative learning, but its neurophysiological mechanism remains unclear. Here, we tested the hypothesis that RPEs modulate declarative learning via theta-frequency oscillations, which have been related to memory encoding in prior work. For that purpose, we examined the interaction between RPE and transcranial Alternating Current Stimulation (tACS) in declarative learning. Using a between-subject (real versus sham stimulation group), single-blind stimulation design, 76 participants learned 60 Dutch-Swahili word pairs, while theta-frequency (6 Hz) tACS was administered over the medial frontal cortex (MFC). Previous studies have implied MFC in memory encoding. We replicated our previous finding of signed RPEs (SRPEs) boosting declarative learning; with larger and more positive RPEs enhancing memory performance. However, tACS failed to modulate the SRPE effect in declarative learning and did not affect memory performance. Bayesian statistics supported evidence for an absence of effect. Our study confirms a role of RPE in declarative learning, but also calls for standardized procedures in transcranial electrical stimulation.
- Subjects :
- Male
Physiology
Social Sciences
EPISODIC MEMORY
Stimulation
PREFRONTAL CORTEX
Memory performance
Transcranial Direct Current Stimulation
Learning and Memory
Cognition
Electronics Engineering
Medicine and Health Sciences
Psychology
Single-Blind Method
Prefrontal cortex
Declarative learning
Episodic memory
GAMMA OSCILLATIONS
Transcranial alternating current stimulation
Brain Mapping
Multidisciplinary
Neuronal Plasticity
General Medicine
PHASE SYNCHRONIZATION
COMMON MECHANISM
Cognitive Linguistics
Frontal Lobe
Electrophysiology
Word Recognition
MEDIAL FRONTAL-CORTEX
Bioassays and Physiological Analysis
Brain Electrophysiology
Medicine
Engineering and Technology
Sensory Perception
Female
General Agricultural and Biological Sciences
Research Article
Adult
Boosting (machine learning)
Adolescent
Science
Neurophysiology
Genetics and Molecular Biology
Surgical and Invasive Medical Procedures
Affect (psychology)
Neurophysiological mechanism
Research and Analysis Methods
ENTRAINMENT
Young Adult
WORKING-MEMORY
Reward
Memory
Neuroplasticity
Functional electrical stimulation
Learning
Humans
Transcranial Alternating Current Stimulation
Transcranial Stimulation
Electrodes
Functional Electrical Stimulation
Working memory
Electrophysiological Techniques
Cognitive Psychology
Biology and Life Sciences
Linguistics
Bayes Theorem
Medial frontal cortex
BRAIN-STIMULATION
ANTERIOR CINGULATE
Reference Electrodes
Brain stimulation
Cellular Neuroscience
General Biochemistry
Cognitive Science
Perception
Electronics
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 15
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....92ccc2e51e2db2b81179b007f9df60ea