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Potential of Environmental Enrichment to Prevent Transgenerational Effects of Paternal Trauma
- Source :
- Neuropsychopharmacology. 41:2749-2758
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Adverse experiences in early life are risk factors for the development of behavioral and physiological symptoms that can lead to psychiatric and cognitive disorders later in life. Some of these symptoms can be transmitted to the offspring, in some cases by non-genomic mechanisms involving germ cells. Using a mouse model of unpredictable maternal separation and maternal stress, we show that postnatal trauma alters coping behaviors in adverse conditions in exposed males when adult and in their adult male progeny. The behavioral changes are accompanied by increased glucocorticoid receptor (GR) expression and decreased DNA methylation of the GR promoter in the hippocampus. DNA methylation is also decreased in sperm cells of exposed males when adult. Transgenerational transmission of behavioral symptoms is prevented by paternal environmental enrichment, an effect associated with the reversal of alterations in GR gene expression and DNA methylation in the hippocampus of the male offspring. These findings highlight the influence of both negative and positive environmental factors on behavior across generations and the plasticity of the epigenome across life.
- Subjects :
- Male
Stress Disorders, Traumatic
0301 basic medicine
Offspring
Physiology
Hippocampus
610 Medicine & health
10071 Functional Genomics Center Zurich
Dark Adaptation
Environment
Biology
2738 Psychiatry and Mental Health
Mice
03 medical and health sciences
Receptors, Glucocorticoid
0302 clinical medicine
Glucocorticoid receptor
Pregnancy
Adaptation, Psychological
Avoidance Learning
Animals
Pharmacology
Regulation of gene expression
Maternal deprivation
Environmental enrichment
Water Deprivation
Maternal Deprivation
Epigenome
DNA Methylation
Mice, Inbred C57BL
Disease Models, Animal
Psychiatry and Mental health
3004 Pharmacology
030104 developmental biology
Animals, Newborn
Gene Expression Regulation
Prenatal Exposure Delayed Effects
DNA methylation
570 Life sciences
biology
Original Article
Female
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 1740634X and 0893133X
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Neuropsychopharmacology
- Accession number :
- edsair.doi.dedup.....92c9d660fe14c49e41baa62c6c4f4c7c