Back to Search
Start Over
Dairy products and pancreatic cancer risk: a pooled analysis of 14 cohort studies
- Source :
- Annals of Oncology, 25(6), 1106-1115. Oxford University Press, Annals of Oncology, 6, 25, 1106-1115
- Publication Year :
- 2014
-
Abstract
- Pancreatic cancer has few early symptoms, is usually diagnosed at late stages, and has a high case-fatality rate. Identifying modifiable risk factors is crucial to reducing pancreatic cancer morbidity and mortality. Prior studies have suggested that specific foods and nutrients, such as dairy products and constituents, may play a role in pancreatic carcinogenesis. In this pooled analysis of the primary data from 14 prospective cohort studies, 2212 incident pancreatic cancer cases were identified during follow-up among 862 680 individuals. Adjusting for smoking habits, personal history of diabetes, alcohol intake, body mass index (BMI), and energy intake, multivariable study-specific hazard ratios (MVHR) and 95% confidence intervals (CIs) were calculated using the Cox proportional hazards models and then pooled using a random effects model. There was no association between total milk intake and pancreatic cancer risk (MVHR = 0.98, 95% CI = 0.82-1.18 comparing ≥500 with 1-69.9 g/day). Similarly, intakes of low-fat milk, whole milk, cheese, cottage cheese, yogurt, and icecream were not associated with pancreatic cancer risk. No statistically significant association was observed between dietary (MVHR = 0.96, 95% CI = 0.77-1.19) and total calcium (MVHR = 0.89, 95% CI = 0.71-1.12) intake and pancreatic cancer risk overall when comparing intakes ≥1300 with
- Subjects :
- Male
25-HYDROXYVITAMIN D
pancreatic cancer
NUTRITIONAL FACTORS
VITAMIN-D STATUS
LS - Life Style
DIETARY ASSESSMENT
Cohort Studies
Cancer risk
REGRESSION-MODELS
Cheese
Food intake
Risk Factors
calcium intake
Medicine
Vitamin D
Prospective cohort study
Risk assessment
Hazard ratio
Smoking
Hematology
Milk
Oncology
Body mass
Health
Yoghurt
FOOD-FREQUENCY QUESTIONNAIRE
Female
Sex
Cohort analysis
pooled analysis
Pancreas adenocarcinoma
Healthy Living
Cohort study
Human
Adult
Ice cream
medicine.medical_specialty
NUTRIENT INTAKE
Adolescent
Reviews
Major clinical study
Vitamin intake
Calcium intake
Pooled analysis
Behavioural Changes
Internal medicine
Pancreatic cancer
Humans
Risk factor
Aged
Proportional Hazards Models
business.industry
Proportional hazards model
dairy products
Very elderly
medicine.disease
Diet
Pancreatic Neoplasms
Endocrinology
PHYSICAL-ACTIVITY
CALIFORNIA TEACHERS
GLYCEMIC INDEX
ELSS - Earth, Life and Social Sciences
Healthy for Life
business
Body mass index
Dairy products
Subjects
Details
- Language :
- English
- ISSN :
- 09237534
- Database :
- OpenAIRE
- Journal :
- Annals of Oncology, 25(6), 1106-1115. Oxford University Press, Annals of Oncology, 6, 25, 1106-1115
- Accession number :
- edsair.doi.dedup.....92beffe832d345f1808050d6ae41a6d3